Table 2.
Summary of all regression analysis r values from comparisons of Bayesian estimated pharmacokinetic parameters obtained using PKB-est to the true values (correlations of significance are depicted in Figs. 3-5). Significant relationships (P < 0.01) are denoted as *.
| Parameters | One-compartment linear elimination | Two-compartment linear elimination | One-compartment nonlinear elimination |
|---|---|---|---|
| CL/F | 0.92* | 0.95* | − |
| Vdss/F | 0.44* | 0.68* | 0.35* |
| Vc/F | − | 0.32* | − |
| t½α | − | 0.62* | − |
| t½β | 0.75* | 0.17* | − |
| ka | 0.17 | 0.23 | 0.076 |
| Vmax | − | − | 0.60* |
| km | − | − | 0.17 |
| CLint | − | − | 0.76* |
CL, clearance; Vdss, volume of distribution at steady state; Vc, volume of central compartment; t½α, distribution halflife; t½β, elimination half-life; ka, absorption rate constant; Vmax, maximum velocity; km, Michaelis-Menten constant; CLint, intrinsic clearance.