Table 1.

Age-Adjusted Incidence rates (IR) per 1,000,000, annual percentage change (APC), and incidence rate ratios (IRR) of marginal zone lymphoma (MZL) according to major MZL subtypes and selected extranodal MZL sites, overall and by sex, United States, SEER-18, 2001–2017.

		Total				Males			Females			Male to Female
MZL subtype¶	ICD-O-3§ Site Code	N	%	IR	APC	N	IR	APC	N	IR	APC	IRR
All MZL	C00.0–80.9	29,066		19.6	1.0*	13,527	20.5	1.0*	15,539	19.1	0.9*	1.07*
Splenic MZL	C42.2	2,592	8.9%	1.7	1.4*	1,254	1.9	1.5*	1,338	1.6	1.1	1.17*
Nodal MZL	C77.0–77.9	8,809	30.3%	6.0	0.5	4,242	6.5	0.5	4,567	5.6	0.5	1.15*
Extranodal MZL		17,665	60.8%	11.9	1.1*	8,031	12.1	1.2*	9,634	11.9	1.1*	1.02
Oral Cavity/ Oropharynx	C01.9–06.9, 09.0–10.9,14.2	403	1.4%	0.27	−0.1	169	0.3	0.0	234	0.3	−0.3	0.90
Salivary Glands	C07.9–08.9	1226	4.2%	0.83	−1.3	360	0.5	0.0	866	1.1	−1.6	0.48*
Nasopharynx	C11.0–11.9	119	0.4%	0.08	−2.1	63	0.1	−4.4*	56	0.1	0.0	1.33
Stomach	C16.0–16.9	5349	18.4%	3.6	−1.7*	2652	4.0	−2.1*	2697	3.3	−1.4*	1.22*
Small Intestine	C17.0–17.9	504	1.7%	0.34	−1.8	263	0.4	−1.8	241	0.3	−1.8	1.32*
Colorectal	C18.0–20.9	855	2.9%	0.57	0.2	440	0.7	2.0*	415	0.5	−1.5	1.30*
Lung	C34.0–34.9	1556	5.4%	1.05	2.1*	662	1.0	1.1	894	1.1	2.7*	0.91*
Skin	C44.0–44.9	1798	6.2%	1.21	4.8*	1009	1.5	4.3*	789	1.0	5.4*	1.47*
Soft Tissue	C38.0, 47.0–47.9, 49.0–49.9	371	1.3%	0.25	0.01	141	0.2	−0.3	230	0.3	−0.1	0.77*
Breast	C50.0–50.9	591	2.0%	0.4	1.3	27	0.04	---	564	0.7	1.2*	0.06*
Kidney and Bladder	C64.9–67.9	217	0.7%	0.15	3.0	110	0.2	0.8	107	0.1	4.8	1.27
Eye/Adnexa	C69.0–69.9	2149	7.4%	1.45	0.4	953	1.4	0.7	1196	1.5	0.2	0.95
Thyroid	C73.9	350	1.2%	0.23	−0.6	115	0.2	0.8	235	0.3	−1.1	0.56*

^¶According to InterLymph Classification as implemented in SEER^*Stat

^§International Classification of Diseases – Oncology, 3^rd Edition

^*P<0.05