Figure 2.
Assessment of neutralizing antibodies after infection
Neutralizing titers were measured at all time points using a pseudovirus neutralization assay. Lines represent linear regression best-fit lines. Each point represents the ID50, or the concentration of plasma that achieves 50% neutralization, which is the average from 2 replicate assays, each containing 2 technical replicates. Black lines: all participants, blue dots/lines: participants without fever, red dots/lines: participants with fever.
(A) Participants with fever had higher neutralizing antibody titers including data from all time points (delta: 0.36, p = 0.01).
(B) Neutralizing titers declined over time (delta per month: −0.10, p = 0.001), and the rate of decay was not modified by fever.
(C) Neutralizing titers by participant, with most participants demonstrating a rapid loss of neutralizing titers over time.
(D) ID50 titers for the only participant in the study who showed increased neutralization over time.