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. 2021 Apr 5;2(4):100253. doi: 10.1016/j.xcrm.2021.100253

Figure 3.

Figure 3

Anti-S avidity increases over time

S and RBD avidity measured in a chaotrope-modified ELISA. Each point represents the average value from 2 replicate assays, each containing 2 technical replicates. Lines represent linear regression best fit lines. Black lines: all participants,blue dots/lines: participants without fever, red dots/ lines: participants with fever. Dotted lines: 95% confidence band.

(A and B) S avidity over time (A) and RBD avidity over time (B). Considering all time points, those with fever had higher S avidity (delta: 0.09, p = 0.04) and a trend toward higher RBD avidity (delta: 0.06, p = 0.1). Those without fever had a faster rate of increase in RBD avidity, however, by 6 months those with and without fever had similar avidity for both antigens.

(C and D) Considering all time points, (C) S avidity (R2 = −0.18, p = 0.2) and (D) RBD avidity (R2 = −0.07, p = 0.5) did not predict neutralization titers.