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. Author manuscript; available in PMC: 2021 Apr 5.
Published in final edited form as: Methods Mol Biol. 2019;1937:227–234. doi: 10.1007/978-1-4939-9065-8_14

Fig. 2.

Fig. 2

Comparison of mice after retrograde renal vein injection of rAAV9-CMV-luciferase and rAAV9-P1-luciferase visualized by IVIS. We can observe that even if the retrograde renal vein injection was performed in the left kidney, both left and right kidneys express the transgene, as well as other organs like the liver and spleen. In contrast, using a kidney-specific promoter (P1 = parathyroid hormone receptor “kidney-specific” promoter), we can significantly restrict luciferase expression in kidneys (right panel) compared to a ubiquitous promoter (left panel)