Table 3.
Estimated ORs and 95% CIs from multivariablea risk models for pancreatic cancer
| Clinical model | Clinical/genetic model | Clinical/genetic/biomarker model | |
|---|---|---|---|
| Full follow-up period | |||
| Model comparison (P valueb) | 3.24e-08 | 6.03e-05 | |
| Model AUC | 0.61 | 0.65 | 0.67 |
| OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Body mass indexc | 1.08 (0.97, 1.21) | 1.07 (0.95, 1.20) | 0.98 (0.86, 1.10) |
| Waist-to-hip ratioc | 1.13 (1.01, 1.26) | 1.12 (1.00, 1.26) | 1.08 (0.96, 1.21) |
| Physical activityc | 0.96 (0.86, 1.06) | 0.95 (0.85, 1.06) | 0.97 (0.86, 1.08) |
| Diagnosed diabetes (yes) | 2.10 (1.16, 3.79) | 2.19 (1.19, 4.02) | 1.70 (0.91, 3.19) |
| wGRSc | 1.37 (1.22, 1.53) | 1.36 (1.21, 1.52) | |
| Proinsulinc | 1.16 (1.03, 1.31) | ||
| Adiponectin (≥ 4.4 ug/ml) | 0.76 (0.58, 0.99) | ||
| Interleukin-6c | 1.10 (0.99, 1.23) | ||
| Total BCAAsc | 1.25 (1.04, 1.51) | ||
| 0–10 years follow-up period | |||
| Model comparison (P valueb) | 2.91e-07 | 2.92e-03 | |
| Model AUC | 0.61 | 0.67 | 0.69 |
| OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Body mass indexc | 1.05 (0.91, 1.22) | 1.04 (0.90, 1.21) | 0.96 (0.82, 1.12) |
| Waist-to-hip ratioc | 1.08 (0.93, 1.25) | 1.06 (0.91, 1.23) | 1.00 (0.86, 1.17) |
| Physical activityc | 0.86 (0.74, 1.00) | 0.86 (0.74, 1.01) | 0.88 (0.75, 1.03) |
| Diagnosed diabetes (yes) | 2.22 (1.09, 4.54) | 2.14 (1.02, 4.50) | 1.65 (0.77, 3.56) |
| wGRSc | 1.44 (1.25, 1.67) | 1.43 (1.23, 1.65) | |
| Proinsulinc | 1.10 (0.94, 1.27) | ||
| Adiponectin (≥ 4.4 ug/ml) | 0.70 (0.48, 1.02) | ||
| Interleukin-6c | 1.13 (0.98, 1.30) | ||
| Total BCAAsc | 1.24 (1.00, 1.54) | ||
AUC, Area under the ROC curve; OR, odds ratio; CI, confidence interval; BCAAs, branched-chain amino acids; wGRS, weighted genetic risk score.
a
Adjusted for matching factors, age, cohort (also gender), race/ethnicity, smoking status, fasting status, and month/year of blood collection.
b
P value was estimated from the likelihood ratio test comparing the clinical/genetic model to the clinical model and the clinical/genetic/biomarker model to the clinical/genetic model.
c
Standardized variables with mean = 0 and SD= 1 within each cohort