Table 4.
Diagnostic performance of rs-EPI DWI and DCE-MRI for characterizing the breast cancers with pathology as reference standard.
| Results (n) | Test performance (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Imaging modality | TP | TN | FP | FN | Sens. | Spec. | PPV | NPV | Acc. |
| rs-EPI DWI | |||||||||
| Overall | |||||||||
| R1 | 211 | 174 | 29 | 9 | 95.9 (211/220) [92.4–97.8] | 85.7 (174/203) [80.2–89.9] | 87.9 (211/240) [83.2–91.5] | 95.1 (174/183) [90.9–97.4] | 91.0 (385/423) [87.9–93.4] |
| R2 | 215 | 175 | 28 | 5 | 97.7 (215/220) [94.8–99.0] | 86.2 (175/203) [80.8–90.3] | 88.5 (215/243) [83.9–91.9] | 97.2 (175/180) [93.7–98.8] | 92.2 (390/423) [89.3–94.5] |
| Mass-like lesion | |||||||||
| R1 | 174 | 170 | 22 | 7 | 96.1 (174/181) [92.2–98.1] | 88.5 (170/192) [83.3–92.3] | 88.8 (174/196) [83.6–92.5] | 96.0 (170/177) [92.1–98.1] | 92.2 (344/373) [89.1–94.5] |
| R2 | 177 | 172 | 20 | 4 | 97.8 (177/181) [94.5–99.1] | 89.6 (172/192) [84.5–93.2] | 89.8 (177/197) [84.8–93.3] | 97.7 (172/176) [94.3–99.1] | 93.6 (349/373) [90.6–95.6] |
| Non-mass-like lesion | |||||||||
| R1 | 37 | 4 | 7 | 2 | 94.9 (37/39) [83.1–98.6] | 36.4 (4/11) [15.2–64.6] | 84.1 (37/44) [70.6–92.1] | 66.7 (4/6) [30.0–90.3] | 82.0 (41/50) [69.2–90.2] |
| R2 | 38 | 3 | 8 | 1 | 97.4 (38/39) [86.8–99.6] | 27.3 (3/11) [9.7–56.6] | 82.6 (38/46) [69.3–90.9] | 75.0 (3/4) [30.1–95.4] | 82.0 (41/50) [69.2–90.2] |
| DCE-MRI | |||||||||
| Overall | |||||||||
| R1 | 216 | 172 | 31 | 4 | 98.2 (216/220) [95.4–99.3] | 84.7 (172/203) [79.1–89.0] | 87.4 (216/247) [82.7–91.0] | 97.7 (172/176) [94.3–99.1] | 91.7 (388/423) [88.7–94.0] |
| R2 | 218 | 164 | 39 | 2 | 99.1 (218/220) [96.8–99.8] | 80.8 (164/203) [74.8–85.6] | 84.8 (218/257) [79.9–88.7] | 98.8 (164/166) [95.7–99.7] | 90.3 (382/423) [87.1–92.8] |
| Mass-like lesion | |||||||||
| R1 | 177 | 167 | 25 | 4 | 97.8 (177/181) [94.5–99.1] | 87.0 (167/192) [81.5–91.0] | 87.6 (177/202) [82.4–91.5] | 97.7 (167/171) [94.1–99.1] | 92.2 (344/373) [89.1–94.5] |
| R2 | 179 | 161 | 31 | 2 | 98.9 (179/181) [96.1–99.7] | 83.9 (161/192) [78.0–88.4] | 85.2 (179/210) [79.8–89.4] | 98.8 (161/163) [95.6–99.7] | 91.2 (340/373) [87.8–93.6] |
| Non-mass-like lesion | |||||||||
| R1 | 39 | 5 | 6 | 0 | 100 (39/39) [91.0–100] | 45.5 (5/11) [21.3–72.0] | 86.7 (39/45) [73.8–93.7] | 100 (5/5) [56.6–100] | 88.0 (44/50) [76.2–94.4] |
| R2 | 39 | 3 | 8 | 0 | 100 (39/39) [91.0–100] | 27.3 (3/11) [9.7–56.6] | 83.0 (39/47) [69.9–91.1] | 100 (3/3) [43.9–100] | 84.0 (42/50) [71.5–91.7] |
TP, true positive; TN, true negative; FP, false positive; FN, false negative; Sens., sensitivity; Spec., specificity; PPV, positive predictive value; NPV, negative predictive value; Acc., Accuracy; R1, reader 1; R2, reader 2; rs-EPI DWI, readout-segmented echo-planar imaging diffusion-weighted imaging; DCE-MRI, dynamic contrast-enhanced MRI.
Data in parentheses are the numerator and denominator. Data in brackets are 95% CIs.