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[Preprint]. 2021 Apr 1:2021.03.31.437931. [Version 1] doi: 10.1101/2021.03.31.437931

Figure 1. A LD/SD vaccine regimen elicits superior CD8 T cells compared to a SD/SD vaccine regimen.

Figure 1.

(A) Experimental approach for evaluating how the priming dose of an Ad5-SARS-2 spike vaccine affects CD8 T cell responses in C57BL/6 mice. (B) Representative FACS plots showing the frequencies of SARS CoV-2-specific CD8 T cells (Kb VL8+) in PBMCs. (C) Summary of SARS CoV-2-specific CD8 T cell responses in PBMCs. (D) Representative FACS plots showing the frequencies of SARS CoV-2-specific CD8 T cells (Kb VL8+) in tissues. (E) Summary of SARS CoV-2-specific CD8 T cell responses in tissues. Data are from one experiment with n=5 per group. Experiment was repeated two additional times with similar results. Indicated P values were determined by Mann-Whitney U test. Error bars represent SEM.