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[Preprint]. 2021 Apr 1:2021.03.31.437931. [Version 1] doi: 10.1101/2021.03.31.437931

Figure 7. A LD/SD vaccine regimen elicits antibody responses with superior recall potential compared to a SD/SD vaccine regimen.

Figure 7.

Experimental approach was similar to Figure 1A. (A) Summary of SARS CoV-2 specific antibody responses in sera. (B) Representative FACS plots showing the frequencies of germinal center B cells in spleen (cells are gated on CD3− B220+ IgM− IgD−). (C) Summary of germinal center B cells in spleen. (D) Summary of SARS CoV-2 neutralizing antibody responses in sera. (E) Summary of cross-reactive (SARS CoV-1) antibody responses in sera. Data in panels D-E are from d7 post-boost (week 5). Data are from one experiment with n=4–5 per group. Experiment was repeated once with similar results. Indicated P values were determined by Mann-Whitney U test. Error bars represent SEM.