TABLE 3. Protein levels in BALF of COVID-19 patients, ARDS patients with non COVID-19 etiology, and patients suffering from non-infectious lung pathologies.
Characteristics and protein production levels (pg/ml) of patients analyzed in Figure 2. BALF from patients suffering from: non-COVID-19 ARDS (divided in H1N1 Influenza A virus positive or not), fibrosis, sarcoidosis, and that received lung transplant was analyzed. Y=yes, N=no, NA=not available.
| Protein concentration in BALF (pg/ml) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sample group | Deceased | Age | IL-1β | IL-6 | CXCL10 | TNF-α | IFN-λ1 | IL-8 | IL-12 | IFN-α2 | IFN-λ2,3 | IFN-β | IL-10 | IFN-γ |
| COVID-19 | Y | 66 | 183.30 | 95.38 | 102.09 | 13.24 | 11.30 | 3223.65 | 8.44 | 12.79 | 0.00 | 9.72 | 7.92 | 9.28 |
| COVID-19 | N | 60 | 1.01 | 71.46 | 1486.57 | 9.52 | 13.60 | 94.78 | 1.49 | 2.27 | 52.05 | 16.44 | 1.94 | 9.28 |
| COVID-19 | N | 53 | 73.74 | 30.38 | 121.58 | 8.80 | 7.42 | 3035.86 | 1.39 | 2.75 | 13.70 | 3.50 | 3.82 | 3.44 |
| COVID-19 | Y | 79 | 4.45 | 20.89 | 183.51 | 0.00 | 7.42 | 749.52 | 0.73 | 2.04 | 42.65 | 0.00 | 1.20 | 5.16 |
| COVID-19 | N | 43 | 296.71 | 190.06 | 1301.64 | 37.22 | 40.87 | 16123.19 | 0.96 | 2.51 | 0.00 | 0.00 | 4.30 | 1.02 |
| COVID-19 | N | 60 | 0.53 | 2.90 | 77.58 | 1.68 | 5.08 | 187.20 | 0.68 | 0.70 | 0.00 | 0.00 | 0.41 | 0.33 |
| COVID-19 | N | 64 | 2.94 | 21.72 | 273.63 | 1.68 | 30.25 | 588.13 | 3.17 | 4.54 | 42.65 | 2.80 | 1.56 | 0.33 |
| COVID-19 | Y | 49 | 0.56 | 27.92 | 656.47 | 0.00 | 5.86 | 173.50 | 0.68 | 0.98 | 0.00 | 0.00 | 1.20 | 0.53 |
| COVID-19 | Y | 61 | 1.47 | 245.69 | 2295.52 | 0.00 | 12.83 | 342.37 | 0.82 | 1.08 | 33.10 | 31.61 | 83.51 | 27.25 |
| COVID-19 | NA | NA | 2.44 | 6.33 | 20.44 | 3.41 | 12.83 | 394.64 | 2.54 | 7.40 | 70.35 | 9.72 | 2.49 | 3.44 |
| COVID-19 | NA | 78 | 14.41 | 553.58 | 2745.27 | 21.04 | 21.78 | 8129.94 | 1.30 | 3.50 | 33.10 | 37.40 | 13.18 | 41.35 |
| COVID-19 | N | 51 | 0.53 | 21.31 | 1161.90 | 4.04 | 13.60 | 352.82 | 0.79 | 1.08 | 48.90 | 6.02 | 5.69 | 3.77 |
| COVID-19 | N | 60 | 2.44 | 3.57 | 118.58 | 6.00 | 11.30 | 166.48 | 0.87 | 0.98 | 48.90 | 0.00 | 1.56 | 0.77 |
| COVID-19 | Y | 60 | 5.97 | 12.77 | 1.44 | 7.38 | 18.11 | 2626.95 | 0.76 | 1.49 | 58.20 | 0.00 | 0.62 | 1.86 |
| COVID-19 | NA | 51 | 5.46 | 14.02 | 6.54 | 2.81 | 15.87 | 2484.53 | 0.90 | 2.75 | 82.25 | 2.80 | 1.20 | 4.46 |
| COVID-19 | NA | 60 | 4.45 | 1.00 | 4.46 | 6.00 | 15.11 | 39.78 | 1.02 | 1.82 | 61.25 | 2.11 | 0.87 | 2.16 |
| COVID-19 | N | 65 | 2.94 | 3.92 | 9.41 | 7.38 | 12.07 | 161.61 | 1.59 | 3.25 | 79.30 | 5.30 | 1.31 | 4.11 |
| COVID-19 | N | 58 | 1.95 | 2.41 | 6.54 | 4.68 | 16.62 | 343.84 | 1.30 | 3.25 | 55.15 | 2.80 | 1.81 | 4.46 |
| COVID-19 | Y | 68 | 6.48 | 2.26 | 8.49 | 5.33 | 12.83 | 2431.50 | 1.36 | 3.00 | 20.20 | 6.39 | 1.37 | 3.11 |
| COVID-19 | N | 66 | 61.58 | 100.99 | 598.68 | 29.89 | 18.11 | 1761.78 | 1.86 | 4.54 | 61.25 | 12.70 | 1.68 | 8.12 |
| COVID-19 | N | 77 | 1478.75 | 79.49 | 59.01 | 0.00 | 7.39 | 22011.22 | 0.00 | 0.00 | 0.00 | 0.00 | 10.90 | 0.00 |
| COVID-19 | Y | 72 | 0.00 | 45.83 | 0.00 | 1939.57 | 23.94 | 2377.05 | 0.00 | 0.00 | 0.00 | 22.95 | 1.74 | 0.00 |
| COVID-19 | NA | 68 | 0.00 | 11.81 | 0.00 | 81.85 | 6.30 | 75.75 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| COVID-19 | NA | 56 | 0.00 | 28.46 | 0.00 | 787.86 | 10.66 | 772.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| COVID-19 | NA | 60 | 0.00 | 0.00 | 0.00 | 22.78 | 5.03 | 101.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| COVID-19 | NA | 61 | 293.85 | 5.04 | 13.22 | 0.00 | 6.30 | 11227.67 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| COVID-19 | NA | 28 | 69.54 | 1673.39 | 14.52 | 3080.64 | 51.13 | 20005.44 | 0.00 | 0.00 | 0.00 | 34.56 | 37.42 | 99.73 |
| COVID-19 | NA | 65 | 9.73 | 111.40 | 0.00 | 2415.91 | 29.28 | 10647.53 | 0.00 | 0.00 | 0.00 | 22.17 | 3.77 | 8.74 |
| COVID-19 | NA | 55 | 0.00 | 2.71 | 0.00 | 5.67 | 0.00 | 36.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Fibrosis | NA | 64 | 0.00 | 1.82 | 16.47 | 0.00 | 0.00 | 143.77 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.14 |
| Fibrosis | NA | 80 | 0.00 | 0.00 | 15.75 | 0.00 | 0.00 | 25.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Fibrosis | NA | 74 | 0.00 | 12.86 | 215.41 | 0.00 | 0.00 | 351.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Fibrosis | NA | 83 | 0.00 | 0.00 | 11.30 | 0.00 | 0.00 | 34.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Fibrosis | NA | 73 | 0.00 | 1.97 | 39.07 | 0.00 | 2.50 | 25.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Fibrosis | NA | 69 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 14.76 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Fibrosis | NA | 65 | 0.00 | 0.00 | 26.07 | 0.00 | 3.63 | 44.67 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Fibrosis | NA | 64 | 0.00 | 0.00 | 64.20 | 0.00 | 0.00 | 18.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Fibrosis | NA | 70 | 3.80 | 0.00 | 11.11 | 0.00 | 0.00 | 37.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Fibrosis | NA | 69 | 2.08 | 0.00 | 15.21 | 0.00 | 0.00 | 56.22 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Sarcoidosis | NA | 35 | 4.24 | 4.55 | 39.34 | 2.57 | 2.50 | 38.96 | 2.17 | 3.25 | 0.00 | 6.05 | 2.37 | 4.45 |
| Sarcoidosis | NA | 45 | 4.24 | 5.24 | 103.77 | 1.98 | 5.30 | 81.97 | 1.38 | 2.10 | 0.00 | 0.00 | 1.77 | 2.53 |
| Sarcoidosis | NA | 43 | 3.80 | 6.28 | 111.60 | 0.00 | 0.00 | 57.05 | 0.00 | 1.11 | 0.00 | 0.00 | 0.00 | 2.73 |
| Sarcoidosis | NA | 69 | 0.00 | 2.73 | 41.79 | 1.54 | 0.00 | 61.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Sarcoidosis | NA | 36 | 0.00 | 0.00 | 47.29 | 0.00 | 0.00 | 22.68 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Sarcoidosis | NA | 38 | 0.00 | 2.73 | 8.20 | 0.00 | 0.00 | 24.66 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Sarcoidosis | NA | 53 | 2.08 | 4.55 | 95.47 | 0.00 | 0.00 | 32.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Sarcoidosis | NA | 53 | 0.00 | 35.21 | 909.28 | 0.00 | 0.00 | 71.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.56 |
| Sarcoidosis | NA | 77 | 0.00 | 0.00 | 148.31 | 0.00 | 0.00 | 46.35 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Sarcoidosis | NA | 46 | 0.00 | 3.54 | 77.03 | 0.00 | 0.00 | 27.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Transplant | NA | 56 | 0.00 | 0.00 | 8.98 | 0.00 | 0.00 | 25.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Transplant | NA | 57 | 6.02 | 3.71 | 38.93 | 0.00 | 0.00 | 42.61 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.35 |
| Transplant | NA | 56 | 2.08 | 14.81 | 49.31 | 0.00 | 0.00 | 190.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Transplant | NA | 52 | 2.50 | 1.82 | 9.95 | 0.00 | 2.50 | 25.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Transplant | NA | 55 | 0.00 | 0.00 | 39.20 | 0.00 | 0.00 | 12.93 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Transplant | NA | 67 | 5.58 | 5.58 | 13.00 | 0.00 | 2.50 | 592.59 | 0.00 | 0.99 | 0.00 | 8.06 | 0.00 | 0.00 |
| Transplant | NA | 59 | 0.00 | 0.00 | 5.43 | 0.00 | 0.00 | 44.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Transplant | NA | 35 | 0.00 | 0.00 | 3.85 | 0.00 | 0.00 | 21.75 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Transplant | NA | 35 | 3.36 | 2.89 | 10.72 | 0.00 | 2.50 | 131.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Transplant | NA | 58 | 0.00 | 2.42 | 45.23 | 0.00 | 0.00 | 251.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ARDS (H1N1) | NA | NA | 0.00 | 1495.62 | 4.54 | 3038.57 | 41.89 | 4392.33 | 0.00 | 0.00 | 0.00 | 60.04 | 32.77 | 285.94 |
| ARDS (H1N1) | NA | 42 | 0.00 | 0.00 | 0.00 | 33.90 | 4.78 | 11.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ARDS | NA | 44 | 0.00 | 2.52 | 0.00 | 85.70 | 5.78 | 71.15 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ARDS | NA | 63 | 33.90 | 76.38 | 3.00 | 111.18 | 8.83 | 4411.90 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ARDS (H1N1) | NA | 58 | 0.00 | 48.28 | 0.00 | 20.98 | 6.30 | 913.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ARDS (H1N1) | NA | 67 | 0.00 | 0.00 | 0.00 | 33.09 | 0.00 | 111.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ARDS | NA | 76 | 0.00 | 9.11 | 0.00 | 57.32 | 0.00 | 75.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ARDS (H1N1) | NA | 60 | 0.00 | 24.45 | 3.09 | 281.99 | 7.96 | 3989.16 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ARDS | NA | NA | 0.00 | 4.57 | 0.00 | 10.34 | 4.54 | 936.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |