TABLE 5. Odds ratio of expressing/not each gene across viral load terciles and age groups in SARS-CoV-2 + swabs.

Odds ratio of expressing IFNL2,3, IFNL4, IFNB1, IFNA2, IFNA4, IL1B, and IL6 mRNA in “+++” and “++” with respect to “+” SARS-CoV-2+ swabs in ≥ 70 and < 70 patients was calculated. Odds ratio column indicates the odds ratio and associated 95% confidence interval in brackets. P value column indicates the associated P value for each cohort of patients. Interaction between viral load terciles and age groups (≥70 years vs <70 years) was tested and P values for interaction are indicated. NE=not estimable.

		Age <70		Age ≥70
Outcome/gene	Viral load, mean CT	Odds ratio	P value	Odds ratio	P value	P value for interaction
IFNA2	+	Reference(1.0)		Reference(1.0)		0.38
	++	0.7(0.2,2.2)	0.56	0.5(0.1,1.9)	0.29
	+++	3.2(1.1,9.2)	0.03	0.9(0.2,3.6)	0.88
IFNA4	+	Reference(1.0)		Reference(1.0)		0.03
	++	1.2(0.2,6.1)	0.83	0.6(0.1,2.8)	0.49
	+++	10.8(2.4,48.8)	0.001	0.8(0.2,3.0)	0.69
IFNB1	+	Reference(1.0)		Reference(1.0)		0.15
	++	0.4(0.1,14)	0.16	0.4(0.1,1.7)	0.23
	+++	8.8(2.6,30.1)	<0.001	1.6(0.4,6.8)	0.49
IFNL1	+	Reference(1.0)		Reference(1.0)
	++	NE		NE
	+++	NE		NE
IFNL2,3	+	Reference(1.0)		Reference(1.0)		<0.001
	++	0.7(0.2,2.9)	0.60	0.8(0.2,2.8)	0.68
	+++	22.1(6.0,82.0)	<0.001	1.0(0.4,3.5)	0.96
IFNL4	+	Reference(1.0)		Reference(1.0)		0.13
	++	NE		0.6(0.2,2.6)	0.54
	+++	4.2(1.0,17.6)	0.049	0.6(0.2,2.1)	0.39
IL1B	+	Reference(1.0)		Reference(1.0)		0.08
	++	6.1(1.7,21.2)	0.005	0.6(0.1,3.2)	0.61
	+++	11.4(3.1,42.1)	<0.001	NE
IL6	+	Reference(1.0)		Reference(1.0)		0.82
	++	2.9(0.3,30.1)	0.36	5.9(0.5,63.8)	0.14
	+++	28.1(3.4,233.1)	0.002	80.0(7.9,805.8)	<0.001