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[Preprint]. 2021 Mar 30:2021.03.30.437173. [Version 1] doi: 10.1101/2021.03.30.437173

TABLE 8. Cytokine protein production by blood-derived phagocytes stimulated with an array of PAMPs.

Cytokine protein levels (pg/ml) produced by blood-derived human cDCs, monocytes, PBMCs, and moDCs stimulated with agonists of PRRs as described in Figure 5.

Protein expression (pg/ml)
Cell Type Donor Stimulus IL-1β IL-6 TNF-α IL-8 IL-12 GM-CSF IL-10 IFN-α2 IFN-β IFN-γ IFN-λ IFN-λ CXCL-10
cDCs E LPS 669.40 1857.84 1415.25 12980.52 1.84 16.28 376.92 2.52 31.39 2.93 68.71 33.14 201.59
cDCs E R848 2824.07 16051.43 36891.67 12980.52 17.93 179.58 643.16 184.68 97.04 39.39 149.84 34.44 646.05
cDCs E CpG(C) 17.51 782.85 325.30 12980.52 1.39 6.57 38.48 127.44 193.15 3.72 100.09 27.83 2967.36
cDCs E Poly(I:C) 25.39 1354.00 875.41 12980.52 38.89 3.94 16.90 33.06 362.44 20.95 3099.24 24086.23 2609.32
cDCs E 3p-hpRNA 11.69 27.07 24.49 12980.52 1.44 2.61 7.03 6.84 63.24 2.56 64.80 35.23 688.54
cDCs E cGAMP 34.90 77.73 87.28 11426.56 1.18 1.65 7.82 14.51 159.43 2.98 143.82 83.89 3832.81
cDCs E UNT 14.80 21.33 26.60 12980.52 2.84 3.39 7.33 2.14 25.11 3.59 34.56 42.25 21.70
cDCs F LPS 213.81 7690.11 3287.19 12980.52 2.41 39.06 1611.54 2.13 47.45 2.01 80.53 32.36 380.39
cDCs F R848 943.78 18744.14 48967.75 12980.52 324.37 229.96 1567.48 163.49 119.77 29.02 172.85 43.08 1078.55
cDCs F CpG(C) 12.27 464.81 217.07 12980.52 1.51 5.43 105.46 107.24 135.55 1.74 90.55 31.85 2009.17
cDCs F Poly(I:C) 35.32 2219.54 1122.04 12980.52 30.54 4.62 142.62 40.25 654.86 4.99 6229.43 44905.95 5194.05
cDCs F 3p-hpRNA 17.65 117.45 55.10 12980.52 1.57 3.31 39.52 5.30 53.72 2.51 53.81 26.61 397.85
cDCs F cGAMP 68.13 607.25 175.26 12980.52 2.34 6.44 59.62 34.94 193.43 2.53 349.17 271.88 5904.37
cDCs F UNT 10.96 88.49 28.84 12980.52 1.44 2.35 25.25 2.07 22.60 3.26 41.45 39.51 71.60
cDCs G LPS 146.58 5954.17 4829.11 12980.52 20.16 21.97 516.07 2.39 95.49 3.16 110.30 37.62 874.33
cDCs G R848 969.40 22010.62 54678.72 12980.52 435.92 103.30 676.48 150.21 187.64 198.14 176.31 46.72 3839.31
cDCs G CpG(C) 2.41 262.46 220.75 10190.97 0.94 2.76 10.81 185.35 228.14 2.70 110.09 22.36 12281.65
cDCs G Poly(I:C) 15.90 659.26 643.77 4855.58 10.57 2.50 14.20 33.56 503.39 7.36 3380.39 17971.60 5701.76
cDCs G 3p-hpRNA 10.37 19.16 23.50 11205.41 2.29 2.79 3.74 1.86 27.97 3.80 38.27 35.76 125.53
cDCs G cGAMP 7.81 32.13 20.45 6355.01 1.56 1.75 4.20 11.75 171.65 2.48 85.25 23.98 9575.39
cDCs G UNT 5.31 14.12 10.20 6633.34 2.01 1.49 2.78 1.70 10.76 2.39 48.91 21.67 156.56
cDCs H LPS 1924.87 15510.57 8290.08 12980.52 18.63 21.61 1918.50 2.24 92.48 17.83 119.66 46.72 743.53
cDCs H R848 9729.13 18090.88 38529.53 12980.52 282.96 82.40 775.56 94.51 126.13 195.36 164.84 47.57 1139.58
cDCs H CpG(C) 51.48 375.01 147.29 12980.52 1.84 2.61 51.16 45.80 168.02 2.22 116.19 26.61 3964.15
cDCs H Poly(I:C) 50.97 2116.62 863.64 7433.94 59.81 3.02 43.66 105.67 502.09 43.27 2751.53 27936.23 3193.10
cDCs H 3p-hpRNA 205.88 905.21 733.64 12980.52 11.15 4.09 89.12 12.82 34.67 4.28 62.63 33.92 276.78
cDCs H cGAMP 1310.59 4935.00 2517.20 12980.52 33.59 21.64 55.49 47.93 242.82 40.91 477.89 173.92 4922.21
cDCs H UNT 31.29 200.65 93.18 12980.52 1.94 3.12 24.03 2.16 13.18 2.90 46.00 34.70 107.53
cDCs I LPS 2174.47 16161.72 10013.36 12980.52 57.71 169.07 873.02 2.20 37.00 2.63 98.70 42.25 231.92
cDCs I R848 7761.77 20062.37 39288.45 12980.52 301.40 728.98 359.28 36.98 57.73 47.42 141.89 39.24 283.16
cDCs I CpG(C) 16.17 108.64 68.46 12980.52 1.59 2.26 14.20 2.94 14.15 2.20 54.49 25.65 76.59
cDCs I Poly(I:C) 58.94 2786.44 1671.73 12980.52 64.08 8.25 29.68 46.75 373.49 11.12 2982.68 12720.31 2446.81
cDCs I 3p-hpRNA 290.19 706.74 1003.83 12980.52 10.19 16.14 35.07 2.34 12.37 2.51 67.82 37.08 7.69
cDCs I cGAMP 143.93 1249.73 567.56 12980.52 19.68 10.61 15.28 5.52 76.55 4.31 252.63 111.35 683.99
cDCs I UNT 17.51 47.81 38.43 12980.52 1.64 1.87 2.93 2.04 12.73 2.27 31.98 29.32 19.62
Mo F LPS 3513.49 21636.90 9915.60 12980.52 2.34 119.99 1905.44 1.95 20.33 3.00 87.04 27.83 17.60
Mo F R848 6438.02 22428.54 50072.00 12980.52 20.81 230.22 1114.03 3.15 26.22 7.33 134.49 38.70 56.52
Mo F CpG(C) 42.62 7.86 9.98 11542.58 1.96 1.55 1.86 1.41 1.00 2.70 61.05 26.85 5.47
Mo F Poly(I:C) 24.44 39.22 22.64 3605.22 3.69 1.39 2.48 33.75 153.51 2.36 86.53 23.75 2724.73
Mo F 3p-hpRNA 92.10 8.54 11.98 12980.52 0.94 1.33 1.35 1.63 5.92 1.29 19.10 20.55 26.76
Mo F cGAMP 33.22 22.27 8.91 6027.20 1.08 1.14 1.00 2.32 30.04 0.92 31.98 17.72 392.64
Mo F UNT 21.38 5.43 3.48 12443.51 1.00 1.44 1.23 1.65 1.00 1.52 1.00 15.44 3.40
Mo G LPS 1703.57 17543.60 6082.10 12980.52 3.36 54.32 802.97 1.76 21.03 3.13 79.99 37.35 76.95
Mo G R848 3627.86 19544.95 35927.19 12980.52 23.56 106.66 526.08 2.28 19.56 23.29 112.86 23.05 119.51
Mo G CpG(C) 21.38 3.04 1.00 6087.97 1.00 1.04 1.00 1.00 1.00 1.07 1.00 10.38 13.75
Mo G Poly(I:C) 14.11 27.22 6.53 2247.27 1.14 1.00 1.07 5.70 108.89 1.00 61.05 10.55 777.74
Mo G 3p-hpRNA 59.33 7.79 9.23 12980.52 1.41 1.00 0.98 1.48 4.95 1.99 1.00 1.00 6.94
Mo G cGAMP 11.40 4.73 1.00 4108.01 1.00 1.00 1.00 1.06 23.22 0.90 1.00 1.00 381.70
Mo G UNT 38.75 3.64 6.33 12980.52 2.22 3.02 1.80 1.79 36.36 2.80 15.85 44.19 7.28
Mo H LPS 6695.14 22718.05 13402.44 12980.52 3.51 96.68 1221.47 2.37 21.35 4.77 117.63 40.87 52.84
Mo H R848 >15635.96 24114.85 50393.98 12980.52 28.72 56.39 372.64 5.36 35.48 38.49 129.63 32.62 110.37
Mo H CpG(C) 167.35 51.57 25.11 12980.52 1.57 2.17 2.06 2.14 4.76 3.05 47.83 29.32 7.59
Mo H Poly(I:C) 105.81 37.64 11.75 7011.83 5.93 1.28 1.68 9.51 83.77 2.17 59.12 13.67 820.00
Mo H 3p-hpRNA 209.22 60.98 95.19 12980.52 4.84 3.96 3.77 3.01 7.52 5.96 100.78 65.86 23.16
Mo H cGAMP 165.24 221.41 134.33 5852.75 6.01 4.97 4.25 4.52 34.91 7.59 112.64 45.03 365.58
Mo H UNT 118.07 23.19 35.39 12980.52 4.76 4.78 4.02 3.49 6.71 6.76 97.06 74.16 27.73
Mo J LPS 3226.82 19876.75 9906.00 12980.52 2.66 223.73 742.88 1.76 14.52 2.58 88.05 38.97 11.93
Mo J R848 10545.70 20245.72 36045.80 12980.52 6.50 88.02 233.87 2.24 21.11 4.31 121.06 26.37 37.21
Mo J CpG(C) 76.81 27.07 10.09 12980.52 1.02 1.72 1.56 1.42 1.58 1.63 22.18 18.57 3.63
Mo J Poly(I:C) 69.99 37.70 15.78 9504.33 2.82 1.64 2.03 1.94 13.77 1.97 32.42 19.44 186.84
Mo J 3p-hpRNA 115.74 47.16 74.04 12980.52 1.60 1.41 1.43 1.62 6.65 1.92 1.00 23.05 5.98
Mo J cGAMP 95.85 175.07 139.35 5628.90 1.19 1.44 1.21 1.00 12.15 1.63 12.38 13.10 247.82
Mo J UNT 66.83 10.98 10.20 12980.52 1.44 1.65 1.35 1.90 2.60 2.46 16.95 21.90 6.60
moDCs A LPS 35.74 13891.14 8086.47 7877.43 16.32 10.70 1267.30 0.00 107.63 4.93 41.90 21.54 8177.19
moDCs A R848 113.37 13891.14 8086.47 7877.43 10.68 49.36 3030.42 0.00 84.73 33.12 39.30 25.89 7003.09
moDCs A CpG(C) 0.00 7.94 3.51 2464.81 0.00 4.31 11.42 8.18 15.60 0.00 11.15 0.00 542.03
moDCs A Poly(I:C) 414.14 13891.14 6994.33 7877.43 273.92 4.29 69.42 74.25 192.08 25.88 518.65 28.54 8159.31
moDCs A 3p-hpRNA 6.01 532.87 7.23 6827.05 0.00 0.00 29.07 39.80 89.50 13.22 22.81 0.00 8139.72
moDCs A cGAMP 0.00 184.88 5.42 6094.82 0.00 0.00 16.67 0.00 80.49 0.00 12.36 0.00 8339.62
moDCs A UNT 4.20 103.95 7.77 7877.43 0.00 2.45 11.53 0.00 0.00 0.00 8.01 0.00 116.32
moDCs B LPS 70.20 13891.14 8086.47 7877.43 21.52 117.06 1807.64 0.00 118.18 6.74 53.93 47.09 9401.58
moDCs B R848 68.95 13891.14 8086.47 7877.43 23.15 484.48 5202.55 0.00 33.98 0.00 38.68 0.00 2168.66
moDCs B CpG(C) 0.00 363.29 3.75 7160.52 0.00 3.78 0.00 0.00 0.00 0.00 4.73 0.00 7.46
moDCs B Poly(I:C) 35.40 6096.66 350.41 7877.43 27.20 2.74 0.00 31.04 121.12 0.00 72.84 0.00 8687.62
moDCs B 3p-hpRNA 11.32 4798.42 169.01 7877.43 0.00 0.00 8.87 44.44 99.13 0.00 36.82 0.00 7454.12
moDCs B cGAMP 0.00 648.18 23.34 7320.08 0.00 0.00 0.00 0.00 69.24 0.00 14.47 0.00 5749.35
moDCs B UNT 0.00 3.24 0.00 1932.32 0.00 0.00 0.00 0.00 0.00 0.00 2.24 0.00 10.84
moDCs K LPS 12.09 13891.14 8086.47 7877.43 258.89 2112.18 1872.32 0.00 99.39 115.78 739.20 0.00 5038.89
moDCs K R848 13.02 13891.14 8086.47 7877.43 296.35 3368.22 1505.79 0.00 12.43 23.62 29.15 23.61 162.71
moDCs K CpG(C) 0.00 107.38 8.28 975.35 0.00 3447.82 0.00 0.00 0.00 0.00 3.49 0.00 0.00
moDCs K Poly(I:C) 5.36 1208.52 282.65 896.44 0.00 2707.80 45.47 16.41 126.26 0.00 283.84 0.00 4925.34
moDCs K 3p-hpRNA 0.00 3218.43 370.82 2011.00 21.24 3202.69 20.80 310.05 189.15 17.56 1748.54 0.00 6270.27
moDCs K cGAMP 0.00 91.78 2.15 727.83 0.00 4075.63 13.24 0.00 13.76 0.00 6.88 0.00 791.49
moDCs K UNT 6.05 302.49 231.80 7877.43 0.00 3726.29 21.33 0.00 0.00 0.00 9.06 0.00 26.81
PBMC A LPS 10772.90 13891.14 8086.47 7877.43 30.53 302.33 1178.35 0.00 8.52 5233.32 37.63 0.00 122.09
PBMC A R848 10772.90 13891.14 8086.47 7877.43 57.68 315.29 342.43 61.55 23.62 13111.72 35.96 0.00 627.83
PBMC A CpG(C) 0.00 470.31 48.00 7877.43 0.00 0.00 16.93 2474.42 369.13 17.83 186.12 0.00 12636.64
PBMC A Poly(I:C) 0.00 148.62 3.07 1766.34 0.00 0.00 0.00 46.37 92.79 26.78 85.62 22.12 5502.88
PBMC A 3p-hpRNA 2056.33 1329.20 3106.83 7877.43 52.57 4.35 42.06 2132.72 333.83 13111.72 359.79 21.39 7682.52
PBMC A cGAMP 0.00 56.65 0.00 3063.88 0.00 0.00 0.00 13.91 16.46 12.52 6.99 0.00 795.56
PBMC A UNT 0.00 2.61 0.00 354.97 0.00 0.00 0.00 0.00 0.00 0.00 5.73 0.00 20.44
PBMC B LPS 854.08 13891.14 6203.03 7877.43 0.00 2.69 3674.69 0.00 24.71 95.76 16.92 21.54 1213.38
PBMC B R848 8517.32 13891.14 8086.47 7877.43 23.95 7.26 4948.34 62.19 80.41 4568.50 31.62 0.00 3985.57
PBMC B CpG(C) 0.00 606.33 75.36 1758.59 0.00 0.00 153.81 641.50 187.91 46.92 155.96 0.00 10814.70
PBMC B Poly(I:C) 9.06 461.29 49.34 281.43 69.38 0.00 28.02 73.20 151.32 690.33 549.53 86.62 4469.96
PBMC B 3p-hpRNA 298.99 285.69 99.82 2652.61 6.21 0.00 59.98 3536.23 488.81 2623.30 577.00 21.39 9449.43
PBMC B cGAMP 5.26 123.21 15.49 190.10 0.00 0.00 33.95 37.98 51.58 20.80 59.45 0.00 1151.77
PBMC B UNT 0.00 8.94 0.00 270.49 0.00 0.00 0.00 0.00 0.00 0.00 8.45 0.00 149.91
PBMC C LPS 335.95 13891.14 2242.45 7877.43 0.00 10.29 712.22 0.00 0.00 10.93 13.82 0.00 79.36
PBMC C R848 2198.11 13891.14 8086.47 7877.43 32.58 19.60 846.43 13.55 14.34 348.10 23.11 0.00 372.98
PBMC C CpG(C) 0.00 41.86 5.64 2179.30 0.00 0.00 3.76 0.00 7.90 0.00 7.58 0.00 379.10
PBMC C Poly(I:C) 0.00 17.49 3.38 160.55 0.00 0.00 0.00 13.76 68.05 3.80 25.88 0.00 7818.39
PBMC C 3p-hpRNA 700.53 341.00 1987.97 7877.43 27.61 0.00 78.29 552.81 152.04 629.37 133.57 33.55 7346.96
PBMC C cGAMP 0.00 0.00 2.85 749.05 0.00 0.00 0.00 0.00 8.96 0.00 5.63 0.00 583.23
PBMC C UNT 0.00 0.00 0.00 498.90 0.00 0.00 0.00 0.00 0.00 0.00 3.13 0.00 8.81
PBMC D LPS 245.28 13891.14 2203.29 7877.43 0.00 11.77 515.55 0.00 0.00 14.21 12.77 0.00 39.59
PBMC D R848 1526.18 13891.14 8086.47 7877.43 37.97 14.91 314.42 0.00 10.34 890.77 26.62 0.00 334.90
PBMC D CpG(C) 0.00 11.18 3.54 975.35 0.00 0.00 0.00 0.00 0.00 0.00 5.18 0.00 18.00
PBMC D Poly(I:C) 0.00 10.62 2.35 119.60 0.00 0.00 0.00 2.25 65.59 4.83 15.54 0.00 4222.02
PBMC D 3p-hpRNA 506.60 412.62 1580.51 7877.43 28.05 0.00 39.16 145.30 67.22 1356.65 30.76 0.00 3474.38
PBMC D cGAMP 4.39 0.00 3.56 553.46 0.00 0.00 0.00 0.00 0.00 0.00 7.04 0.00 229.92
PBMC D UNT 5.46 0.00 0.00 471.91 0.00 0.00 0.00 0.00 0.00 3.63 5.53 0.00 95.73
PBMC K LPS 1332.49 13891.14 706.56 7877.43 2.14 150.24 1038.49 0.00 0.00 6.83 11.61 23.61 3.72
PBMC K R848 2689.87 13891.14 8086.47 7877.43 12.42 27.08 351.15 79.43 7.98 192.71 21.34 0.00 60.94
PBMC K CpG(C) 0.00 40.58 0.00 1738.46 0.00 0.00 0.00 8.40 0.00 0.00 3.91 0.00 145.56
PBMC K Poly(I:C) 9.47 307.00 9.39 1777.53 11.58 0.00 0.00 4.06 54.25 0.00 11.84 0.00 544.88
PBMC K 3p-hpRNA 681.23 557.88 364.16 4623.20 23.61 2.58 39.40 498.27 31.04 273.23 42.15 0.00 142.27
PBMC K cGAMP 0.00 18.38 0.00 233.26 0.00 0.00 0.00 0.00 0.00 0.00 5.89 0.00 32.52
PBMC K UNT 0.00 2.61 0.00 279.38 0.00 0.00 0.00 0.00 0.00 0.00 2.61 0.00 0.00