. 2020 Nov 5;12(Suppl 2):S676–S680. doi: 10.4103/jpbs.JPBS_272_19

Table 1.

Docking results for Bcl-2 and Bcl-xl proteins with flavonoids

Protein	Ligand	Binding affinity (kcal/mol)	Hydrogen bonding	Hydrophobic interaction	Electrostatic interaction
Bcl-2	Myricetin	−7.3	–	PHE63	–
Bcl-2	Myricetin	−7.3	–	GLY104	–
	Galangin	−7.3	ARG66	PHE63	–
	Galangin	−7.3	TYR67	PHE63	–
	Apigenin	−7.2	ARG105	PHE63	–
	Fisetin	−7.1	–	–	PHE63
	Biochanin A	−6.9	–	TYR161	ASP62
Bcl-xl	Fisetin	−8.8	ASP133	PHE105	ARG139
			ARG139	ARG139
			GLU129	ALA142
			GLY138	ALA104
	Apigenin	−8.6	ARG139	ALA104	–
	Apigenin	−8.6	ARG139	PHE105	–
	Biochanin A	−8.5	SER106	LEU130	–
			GLU129	ALA104
			ASN136	PHE105
				LEU108
				ARG139
				ALA142
	Myricetin	−8.1	ASP133	PHE105	ARG139
			ARG139	ARG139
			GLU129	ALA104
	Galangin	−8.0	LEU108	LEU130	–
				PHE105
				ALA142
				ARG139
				ALA104
				ARG102
				LEU108