Table 2.
Citation | N | Intervention | Comparison? | Duration | Effect on HbA1c | Effect on dailyInsulin Dose | Effect on Weight |
---|---|---|---|---|---|---|---|
Gomez et al. J Pediatr Endocrinol Metab. 2002. (135) | 10 | Variable dose metformin | No | 6 months | Decrease by 11% of baseline | No change | No change |
Hamilton et al. Diabetes Care. 2003. (120) | 27 | Weight-based dose metformin (up to 2000 mg/day) | Placebo | 3 months | -0.6% (p=0.03) |
-0.16 units/kg (p=0.01) | No change |
Urakami et al. Pediat Int. 2005. (121) | 9 | 500-750 mg twice daily metformin | No | 12 months | -1.1% (p<0.01) |
-6.7 units (p<0.01) |
-0.7 kg/m2
(p<0.05) |
Nadeau et al. Pediatr Diabetes. 2015. (117) | 74 | 1000 mg daily metformin | Placebo | 6 months | No change | No change | No change |
Nwosu et al. PLoS One. 2015. (118) | 28 | 1000 mg daily metformin | Placebo | 9 months | No change | No change | No change |
Libman et al. JAMA. 2015. (119) | 140 | 2000 mg daily metformin | Placebo | 6 months | No change | -0.1 units/kg (p<0.001) | -0.1 BMI z-score (p<0.001) |