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. 2021 Mar 8;6(5):e141673. doi: 10.1172/jci.insight.141673

Figure 1. KLF11 is reduced in the ECs of mouse and human aortic aneurysms.

Figure 1

(A–C) Elastase-induced AAA model in 10-week-old C57BL/6 male mice (n = 4/group). Representative morphology of aortas (A) and quantification of maximal infrarenal aortic diameters (B). En face immunofluorescence staining of KLF11 (shown in green) and VE-cadherin (shown in red, EC marker) in the endothelium of elastase-treated infrarenal aortas (C) and AngII-infused suprarenal abdominal aortas (D and E) from the indicated end time points. Nuclei stained by DAPI are shown in blue. Scale bar: 20 μm. (F) Western blot analysis of KLF11 expression in the ECs from human normal (n = 4) and aneurysmal aortas (n = 5). Data are presented as mean ± SEM. One-way ANOVA followed by Tukey’s post hoc for B, Student’s 2-tailed t test for E.