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. 2021 Mar 8;6(5):e141245. doi: 10.1172/jci.insight.141245

Figure 2. αTIGIT Ab significantly worsens sepsis survival in memory but not previously naive mice.

Figure 2

(A) Schematic of experiment setup for CLP sepsis study in naive mice. (B) All naive mice received CLP surgery and were randomized to receive either αTIGIT Ab (n = 19) or isotype Ab (n = 19) at specified time points. All animals were monitored for 7-day survival. (C) Schematic of experiment setup for memory septic mice. (D) All memory mice received CLP surgery and were randomized to receive either αTIGIT Ab (n = 20) or isotype Ab (n = 20) at 12 and 24 hours after surgery. All animals were monitored for 7-day survival. Results represent 2 independent experiments. The log-rank (Mantel-Cox) test was used to test for significance.