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. 2021 Mar 8;6(5):e141245. doi: 10.1172/jci.insight.141245

Figure 7. αTIGIT Ab differentially affected bacterial load and cytokines in peritoneal fluid in memory versus previously naive septic mice.

Figure 7

Both previously naive and memory septic mice were administered αTIGIT Ab or isotype Ab at12 and 24 hours after CLP, and then were sacrificed at 36 hours after CLP and the sterile peritoneal fluid (PF) was taken for bacterial culture and cytokine detection. (A) Bacterial load in PF was measured in both memory and naive septic mice with or without αTIGIT. (B–D) Summary data of cytokines IL-6, IL-10, and MCP-1 as measured in the PF in the 4 groups. All data are representative of a minimum of 2 independent experiments. Groups were compared using 1-way ANOVA analysis and Tukey’s multiple comparison test. *P < 0.05, **P < 0.01, ***P < 0.001.