Figure 2. Ctsk-Cre⁺Jak2^fl/fl mice demonstrate postnatal growth restriction.

Ctsk-Cre⁺Jak2^fl/fl and littermate control mice were monitored until 6 months of age and growth parameters assessed. (A) Weekly body weights of male control (n = 18) and Ctsk-Cre⁺Jak2^fl/fl (n = 14) mice. (B) Weekly body weights of female control (n = 15) and Ctsk-Cre⁺Jak2^fl/fl (n = 9) mice. (C) Representative photograph of 8-week-old male control (left, n = 16) and Ctsk-Cre⁺Jak2^fl/fl (right, n = 15) mice. Scale bar: 20 mm. (D) Total body length of male control [n = 5 (2 weeks), n = 16 (8 weeks), n = 18 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 5 (2 weeks), n = 15 (8 weeks), n = 14 (24 weeks)] mice. (E) Total body length of female control [n = 4 (2 weeks), n = 18 (8 weeks), n = 15 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 4 (2 weeks), n = 12 (8 weeks), n = 9 (24 weeks)] mice. (F) Representative photograph of femurs from control (left) [n = 3 (P0), n = 9 (2 weeks), n = 34 (8 weeks), n = 33 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl (right) [n = 3 (P0), n = 9 (2 weeks), n = 27 (8 weeks), n = 23 (24 weeks)] mice at 0, 2, 8 and 24 weeks of age. Scale bar: 5 mm. (G) Femur length of male control [n = 5 (2 weeks), n = 16 (8 weeks), n = 18 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 5 (2 weeks), n = 15 (8 weeks), n = 14 (24 weeks)] mice. (H) Femur length of female control [n = 4 (2 weeks), n = 18 (8 weeks), n = 15 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 4 (2 weeks), n = 12 (8 weeks), n = 9 (24 weeks)] mice. Data represent mean ± SEM. Differences between groups were analyzed for statistical significance by repeated measures ANOVA or 2-way ANOVA; ***P < 0.001.