Figure 3. Ctsk-Cre⁺Jak2^fl/fl mice have proportional reduction in bone mineral density.

Excised femurs and lumbar vertebrae 1-3 (LV1-3) from 8- and 24-week-old Ctsk-Cre⁺Jak2^fl/fl and control mice were analyzed by dual x ray absorptiometry (DXA). (A) Femur bone mineral density (BMD) (left panel) and BMD normalized to body length (right panel) in male control [n = 13 (8 weeks), n = 18 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 12 (8 weeks), n = 14 (24 weeks)] mice. (B) Femur BMD (left panel) and BMD normalized to body length (right panel) in female control [n = 18 (8 weeks), n = 16 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 12 (8 weeks), n = 9 (24 weeks)] mice. (C) Lumbar vertebrae 1–3 (LV1–3) BMD (left panel) and BMD normalized to body length (right panel) in male control [n = 10 (8 weeks), n = 18 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 8 (8 weeks), n = 14 (24 weeks)] mice. (D) LV1-3 BMD (left panel) and BMD normalized to body length (right panel) in female control [n = 9 (8 weeks), n = 16 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 4 (8 weeks), n = 9 (24 weeks)] mice. Data represent mean ± SEM. Differences between groups were analyzed for statistical significance by 2-way ANOVA; *P < 0.05, ***P < 0.001.