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. 2021 Mar 8;6(5):e137045. doi: 10.1172/jci.insight.137045

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© 2021 Dodington et al.

This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Musculoskeletal strength of Ctsk-Cre⁺Jak2^fl/fl and control mice was assessed using a materials testing system and grip strength meter. (A) Femur midpoint peak load (left panel) and peak load normalized to body length (right panel) in male control [n = 8 (8 weeks), n = 18 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 7 (8 weeks), n = 14 (24 weeks)] mice. (B) Femur midpoint peak load (left panel) and peak load normalized to body length (right panel) in female control [n = 7 (8 weeks), n = 16 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 5 (8 weeks), n = 9 (24 weeks)] mice. (C) Femur neck peak load (left panel) and peak load normalized to body length (right panel) in male control [n = 8 (8 weeks), n = 18 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 7 (8 weeks), n = 14 (24 weeks)] mice. (D) Femur neck peak load (left panel) and peak load normalized to body length (right panel) in female control [n = 7 (8 weeks), n = 15 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 5 (8 weeks), n = 9 (24 weeks)] mice. (E) Lumbar vertebra 4 (LV4) peak load (left panel) and peak load normalized to body length (right panel) in male control [n = 10 (8 weeks), n = 11 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 8 (8 weeks), n = 8 (24 weeks)] mice. (F) LV4 peak load (left panel) and peak load normalized to body length (right panel) in female control [n = 7 (8 weeks), n = 9 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 5 (8 weeks), n = 6 (24 weeks)] mice. (G) Grip strength (left panel) and grip strength normalized to body length (right panel) in male control [n = 13 (8 weeks), n = 14 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 11 (8 weeks), n = 12 (24 weeks)] mice. (H) Grip strength (left panel) and grip strength normalized to body length (right panel) in female control [n = 11 (8 weeks), n = 16 (24 weeks)] and Ctsk-Cre⁺Jak2^fl/fl [n = 6 (8 weeks), n = 9 (24 weeks)] mice. Data represent mean ± SEM. Differences between groups were analyzed for statistical significance by 2-way ANOVA; *P < 0.05, **P < 0.01, ***P < 0.001.