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. 2021 Mar 8;6(5):e143465. doi: 10.1172/jci.insight.143465

Figure 2. CUG960 mice display reversible conduction abnormalities associated with DM1.

Figure 2

Surface ECG recordings were obtained to evaluate conduction intervals in CUG960 and MHCrtTA control mice given dox chow starting at PN1 for 2 months and then switched to regular chow for 2 months: (A) RR interval (B) PR interval (C) QRS interval and (D) corrected QT interval (QTc). n = 8 animals per group. (E) Overlap of representative ECG tracings from MHCrtTA +dox and CUG960 +dox mice. Data represent the mean ± SD and were analyzed using 2-way ANOVA followed by Tukey’s test for multiple comparisons. **P < 0.01, ****P < 0.0001. DM1, myotonic dystrophy type 1; PN1, postnatal day 1; dox, doxycycline.