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. 2021 Mar 8;6(5):e143465. doi: 10.1172/jci.insight.143465

Figure 3. CUG960 mice exhibit an increased and reversible predisposition to atrial arrhythmias.

Figure 3

(A) Baseline arrhythmias observed in surface ECG recordings for CUG960 +dox mice in comparison with MHCrtTA +dox controls. (B) Incidence of atrial arrhythmias induced by electrical pacing in CUG960 vs. MHCrtTA control mice in response to dox induction initiated at PN1 for 2 months and dox withdrawal for 1 month after 2 months of induction initiated at PN1. (C) Representative recordings of surface and intracardiac atrial electrograms in CUG960 +dox and MHCrtTA +dox control mice after rapid atrial pacing. (D) Representative recordings of surface and intracardiac atrial electrograms in CUG960 +/off dox and MHCrtTA +/off dox control mice after rapid atrial pacing. Numbers of animals analyzed are indicated in corresponding bars. Data were analyzed using Fisher’s exact test. *P < 0.05. Scale bar: 200 milliseconds. PN1, postnatal day 1; dox, doxycycline.