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. 2021 Mar 8;6(5):e140669. doi: 10.1172/jci.insight.140669

Figure 8. Downregulation of ZFP36 expression in human tumor-specific keratinocytes.

Figure 8

(A) Uniform manifold approximation and projection (UMAP) of 18,359 single-cell RNA-Seq keratinocytes recovered from the skin of 7 control individuals and from 7 patients with cutaneous squamous cell carcinoma (cSCC) labeled by subsets and origins. (B) Expression of the indicated genes was measured and visualized on UMAP after separating tumor from normal cells or by violin plots. (C) Enrichment scores of genes that were found to be downregulated (upper panel) or upregulated (lower panel) in Zfp36ΔEP tumor cells visualized on UMAP or by violin plots. Statistical significance (****P < 0.0001) was assessed by 1-way ANOVA with post hoc Tukey’s HSD test.