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. 2021 Mar 8;6(5):e140267. doi: 10.1172/jci.insight.140267

Figure 5. Different cell populations present in the nasal turbinates and lungs after treatment with INNA-X and challenge with influenza virus.

Figure 5

(A and B) Mice (n = 3–5/group) were inoculated with 1 nmol of INNA-X or diluent and 1 day later challenged with 500 PFU of Udorn IAV. (B) Frequencies of cell populations in the nasal turbinates on 1, 3, 5, and 7 days after challenge were analyzed. (C and D) Mice (n = 4/group) were treated with 1 nmol of INNA-X and 3 days later challenged with virus to examine cell populations present 1, 3, 5, and 7 days after challenge. Cell populations present 24 hours (B) or 3 days (D) after treatment but prior to challenge with virus are shown in each panel as the day 0 time point. (E and F) Cell populations in the lungs of inoculated mice (n = 7/group) challenged 1 day later were also analyzed at 5 days after infection. Statistical analysis was performed by (B and D) 2-way ANOVA with a Bonferroni post hoc test or (F) a Welch t test. *P < 0.01. **P < 0.001.