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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Adv Cell Gene Ther. 2020 Jul 3;4(2):e99. doi: 10.1002/acg2.99

Figure 3: SIRPα-Fc-VV has superior antitumor activity in immune-competent osteosarcoma model.

Figure 3:

C57BL/6 mice were injected with 5×105 F420 cells s.c. into the right flank. Once tumors reached ~50–100mm3, mice (n=10 per group) were injected i.t with 1 ×107 PFU of SIRPα-Fc-VV, SIRPα-VV, YFP-VV or PBS (control; Co). Tumor size was monitored by caliper measurements (n=10 per group). (A) Tumor volume (dotted lines: individual mice; solid line: median). (B) Kaplan-Meier survival curves. The Wilcoxon test with Holm method for adjustment of multiple comparisons was used to determine significance.