Fig 1. Geographical distribution and incidence distribution in Hunan Province, Jilin Province, Shenzhen City, Xiamen City, Chuxiong Prefecture, Yunxiao County, and Longde County.

Fig 1A shows the locations and reported cases of in Hunan Province, Jilin Province, Shenzhen City, Xiamen City, Chuxiong Prefecture Yunxiao County, and Longde County in the map of mainland China. The dark grey regions include provinces with severe HFMD outbreaks every year. China can be roughly divided into two parts according to its humidity and temperature: the drier and colder part in the northwest and the more humid and warmer part in the southeast (Fig 1B). Five of the seven regions belong to the subtropical zone and two belongs to the mid-temperate zone. The southeast part includes tropical, subtropical and warm temperate zones; the northwest part includes middle temperate zone, the plateau zone and the middle and warm mixture zone. Fig 1C shows the time series of incidence in Hunan Province, Jilin Province, Shenzhen City, Xiamen City, Chuxiong Prefecture, Yunxiao County, and Longde County. The map depicted in this figure was taken from Wikimedia Commons https://commons.wikimedia.org/wiki/Atlas_of_the_People%27s_Republic_of_China#/media/File:China_Hunan.svg.