. 2021 Apr 5;16(4):e0248765. doi: 10.1371/journal.pone.0248765

Table 1. Values and interpretation of the parameters of the model.

Parameter interpretation	Value	Reference
Human population sample [H]	100 000 per sample	Proposed
Mosquitoes population sample [M]	100 000 per sample	Proposed
Recalculations (loops)	500	Proposed
Initial proportion of urban infected mosquitoes	20%	[40]
Initial proportion of infected humans	0	Supposed
Infectious meal rate from humans to mosquitoes	0.3	[41, 42]
Mortality rate of uninfected mosquito [k]	(−90.66+9.54 T−0.18 T²)⁻¹	[43]
Mortality rate of infected mosquito	1.56 k	[44]
Infectious bites rate from mosquitoes to humans	0.2	[42, 43, 45]
Immunity acquisition rate [R(t)]	0.14	[46]
Immunity loss rate (daily loss)	0.001%	[47]
Extrinsic Incubation Period [EIP]	$600 \sqrt{\frac{0.3}{2 π}} E x p (- 0.3 \frac{{(T - 5.9)}^{2}}{T})$	[48]
Cross protection duration	1–2 weeks	[49]
Mutation rate per amino acid per year	0.35% to 1.39%	[33]
E-protein length	480 amino acids	[50]
Proportion of infective virus	10⁻⁴	[32]
Percentage of sequence identity to define new serotype	40%-80%	[11, 36, 51, 52]
Percentage of persons which enters to the forest to carry out their daily activities	30%–90%	Supposed
Proportion of symptomatic dengue infection in humans	4.2%	[53]
Proportion of sylvatic mosquitoes infected with DENV	1.13%	[54]
Explicit Calculations
Dynamic of human-infected population [I(t)]	$I (t) = \frac{N H I (t - 1) + I (t - 1) - N R H (t - 1) + N S T E (t - 1)}{H}$
Dynamic of human-infected population [R(t)]	$R (t) = \frac{R (t - 1) + N R H (t - 1) - H L I (t - 1)}{H}$
Dynamic of susceptible-human population [S(t)]	S(t) = 1−[I(t−1)+R(t−1)]
Dynamic mosquito-infected population [J(t)]	$J (t) = \frac{N M I (t - 1) + J (t - 1) - D I M (t - 1) + N S C E (t - 1)}{M}$
Temperature	$25 + 5 {S i n (\frac{t}{4 * 30} π)}^{2}$

T = Temperature, t = Time, NSTE = New serotype transmission event, NHI = New human infection, NRH = New recovered human, HLI = Human immunity loss, NMI = New mosquito infection, NSCE = New sequence consolidation events, DIM = Death of infected mosquito.