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Summary of Forced Degradation Experiments of Standard Ambrisentan
| Stressor | Temperature, °C | Time, hr | Recovered Ambrisentan, % | Degradation Products |
|---|---|---|---|---|
| Acid hydrolysis (0.5 N HCl) | 60 | 3 | 1 | At least 1 |
| Base hydrolysis (0.5 N NaOH) | 60 | 8 | 100 | 0 |
| Aqueous hydrolysis | 60 | 8 | 100 | 0 |
| Oxidation (10% H2 O2) | 24 | 24 | 43 | At least 4 |
| Freeze/thaw | −20/24 | 18/6 (×3) | 100 | 0 |
