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. 2021 Apr 1;16:2597–2613. doi: 10.2147/IJN.S295445

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© 2021 Xu et al.

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Schematic illustration of improved efficacy of US-triggered NO release nanosystem mediated platelet blockade. (A) Schematic diagram of preparation of SNO-HSA-PTX nanoparticles. (B) The NO released by SNO-HSA-PTX under US stimulation inhibited platelet activation thus opening the tumor vascular barrier, leading to enhanced T cells infiltration, drug accumulation and tumor hypoxia relief.