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. 2021 Apr 1;16:2597–2613. doi: 10.2147/IJN.S295445

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© 2021 Xu et al.

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SNO-HSA-PTX combined with US irradiation enhanced tumor hemorrhage and relieved tumor hypoxia. (A) Red blood cells infiltration in tumors as visualized by H&E staining 24 h after the treatments of saline, saline+US, SNO-HSA-PTX, or SNO-HSA-PTX+US. The upper right corner was the photo of the representative tumor. Scale bar: 100 μm. (B) The content of hemoglobin inside the tumors detected by the hemoglobin assay kits. **p < 0.01. (C) Laser speckle contrast imaging of blood flow signals in 4T1 tumor-bearing mice after intravenous injection of saline or SNO-HSA-PTX with US irradiation. (D) Flux of blood flow measured by Doppler flow imaging. *p < 0.05, **p < 0.01. (E) HIF-1α staining of tumor sections harvested from mice treated with saline, saline+US, SNO-HSA-PTX or SNO-HSA-PTX+US. Scale bar: 50 μm.