Table 3.
Hazard Ratios and 95% Confidence Intervals for Incident Type 2 Diabetes According to WBC Count Quartiles
| WBC Count Quartiles | ||||
|---|---|---|---|---|
| Q1 (≤ 5200) (n = 1006) | Q2 (5300–6100) (n = 1067) | Q3 (6200–7300) (n = 1115) | Q4 (≥ 7400) (n = 1023) | |
| New cases of diabetes, n | 58 | 75 | 87 | 108 |
| Mean follow-up, years | 8.41 | 8.25 | 7.99 | 7.92 |
| Person-years of follow-up | 8463 | 8807 | 8905 | 8098 |
| Unadjusted | 1.00 | 1.28 (0.91–1.80) | 1.48 (1.06–2.06) | 2.04 (1.48–2.81) |
| Model 1 | 1.00 | 1.23 (0.87–1.73) | 1.42 (1.02–1.98) | 1.96 (1.42–2.70) |
| Model 2 | 1.00 | 1.27 (0.90–1.80) | 1.45 (1.03–2.03) | 1.71 (1.22–2.39) |
| Model 3 | 1.00 | 1.22 (0.96–1.72) | 1.39 (0.99–1.95) | 1.55 (1.10–2.18) |
Notes: Model 1: adjusted for age and sex. Model 2: adjusted for age, sex, smoking, alcohol consumption, waist circumference, systolic blood pressure, fasting plasma glucose, and family history of type 2 diabetes. Model 3: adjusted for age, sex, smoking, alcohol consumption, waist circumference, systolic blood pressure, fasting plasma glucose, family history of type 2 diabetes, HOMA-IR, hsCRP, and prediabetes.
Abbreviations: WBC, white blood cell; HOMA-IR, homeostatic model assessment of insulin resistance; hsCRP, high-sensitivity C-reactive protein.