Table 2.
Transcription Factor Enrichment Following PAMP Stimulation
| KDO | IFNλ-KDO | Poly I:C | IFNλ-Poly I:C | Zymo | IFNλ-Zymo | |
|---|---|---|---|---|---|---|
| IRF1 | 0.0148 | 7.02E-05 | 3.09E-10 | 0.0124 | ns | ns |
| IRF2 | 0.0332 | 8.13E-08 | 2.45E-15 | 6.92E-05 | ns | 0.0244 |
| IRF3 | 5.56E-06 | 2.78E-15 | 1.07E-23 | 2.53E-14 | 9.05E-05 | 9.59E-07 |
| IRF4 | 4.26E-03 | 9.22E-11 | 6.58E-20 | 1.64E-11 | 4.73E-06 | 1.54E-07 |
| IRF5 | 4.44E-03 | 7.06E-08 | 6.83E-14 | 2.93E-08 | 2.10E-06 | 2.90E-05 |
| IRF7 | ns | 0.0006 | 1.42E-11 | 0.0028 | ns | ns |
| IRF8 | 9.00E-04 | 3.37E-11 | 2.53E-21 | 1.49E-12 | 1.82E-05 | 3.17E-08 |
| IRF9 | 1.53E-04 | 6.45E-12 | 2.98E-23 | 5.51E-12 | 1.42E-04 | 3.68E-06 |
| STAT1 | 4.20E-03 | 0.0018 | 2.46E-03 | 0.0237 | ns | ns |
| STAT1:STAT2 | 6.00E-05 | 1.86E-09 | 5.77E-16 | 3.34E-06 | ns | ns |
| STAT3 | 8.77E-03 | 5.74E-03 | 0.0169 | ns | ns | ns |
| NFKB1 | 4.67E-12 | 3.81E-14 | 1.29E-05 | 2.95E-12 | 9.86E-18 | 8.80E-24 |
| NFKB2 | 2.74E-15 | 4.41E-17 | 1.54E-07 | 8.37E-14 | 1.42E-18 | 6.16E-27 |
| RELA | 6.64E-17 | 7.87E-19 | 1.30E-09 | 1.19E-13 | 1.39E-14 | 2.03E-19 |
| RELB | 5.48E-07 | 2.44E-11 | 2.83E-06 | 5.86E-08 | 7.39E-10 | 2.43E-15 |
Note: Shading represents strength of transcription factor enrichment (p value).
Abbreviations: IRF, interferon regulatory factor; STAT, signal transducer and activator of transcription; NFKB, nuclear factor κB; REL, v-rel avian reticuloendotheliosis viral oncogene homolog; ns, non-significant.