Table 3.

Univariate and Multivariate Analyses of Factors Associated with OS of HCC Patients

Variable	Case Number	HR	95% CI	p value
Univariate analysis
circEPB41L2 (high vs low)	50/50	0.289	0.135–0.620	0.001**
Gender(female vs male)	18/82	0.691	0.312–1.529	0.362
Age, years (≥55 vs <55)	48/52	0.444	0.216–0.914	0.028*
Tumor size, cm (≥5 vs<5)	50/50	4.768	2.144–10.599	<0.001***
Tumor number (multiple vs single)	3/97	0.047	0.000–121.437	0.445
AFP, ng/mL (≥400 vs <400)	31/69	3.044	1 0.549–5.980	0.001**
Liver cirrhosis (yes vs no)	79/21	1.080	0.469–2.490	0.856
HBV (positive vs negative)	55/45	2.251	1.090–4.648	0.028*
Vascular invasion (yes vs no)	47/53	3.388	1.618–7.096	0.001**
Tumor capsule (complete vs none)	87/13	0.377	0.169–0.842	0.017*
Metastasis (yes vs no)	5/95	3.823	1.328–11.010	0.013*
BCLC stage (B and C vs A)	13/87	0.582	0.239–1.415	0.232
TNM stage(III–IV vs I–II)	20/80	3.605	1.737–7.482	0.001**
Tumor differentiation (III–IV vs I–II)	69/31	2.817	1.162–6.827	0.022*
Multivariate analysis
CircEPB41L2 (high vs low)	50/50	0.440	0.201–0.961	0.039*
Tumor size, cm (≥5 vs <5)	50/50	3.513	1.558–7.923	0.002**
Vascular invasion (yes vs no)	47/53	2.623	1.242–5.539	0.011*

Notes: *p < 0.05, **p < 0.01, ***p < 0.001.

Abbreviations: AFP, alpha-fetoprotein; HBV, hepatitis B virus; TNM, tumor-node-metastasis; HR, hazard ratio.