Table 2.
Clinical findings, signs, laboratory measures, and severity scores among the randomly assigned supplementation and placebo groups.
Variable | D3 Supplementation group (n = 93) | Placebo group (n = 98) | P |
Temperature | 38 (38–39) | 38 (38–39) | .184∗ |
Respiratory rate | 45 (40–50) | 40 (40–50) | .603∗ |
Mechanical ventilation | 23 (24.7) | 34 (34.7) | .133† |
D1-serum Ca | 7.9 (7.4–8.9) | 8.2 (7.2–9) | .392∗ |
D1-serum creatinine | 0.2 (0.2–0.2) | 0.2 (0.1–0.2) | .079∗ |
D1-serum albumin | 3.5 (2.9–4) | 3.2 (2.9–3.7) | .096∗ |
D1-Bilirubin | 0.3 (0.3–0.3) | 0.3 (0.3–0.4) | .502∗ |
D1-platelet count | 249 (170–370) | 227 (170–300) | .663∗ |
D1-CRP | 55 (35–70) | 57.5 (45–70) | .138∗ |
D1-pSOFA score | 2 (2–3) | 2.5 (2–4) | .344∗ |
D7-serum Ca | 8.9 (8.2–9) | 9 (8–9.2) | .663∗ |
D7-serum creatinine | 0.2 (0.2–0.2) | 0.2 (0.1–0.2) | .220∗ |
D7-serum albumin | 3.7 (3.5–4) | 3.7 (3.1–4) | .066∗ |
D7-Bilirubin | 0.3 (0.3–0.3) | 0.3 (0.2–0.3) | .070∗ |
D7-platelet count | 300 (250–350) | 250 (250–300) | .017∗ |
D7-CRP | 6 (6–6) | 6 (5–35) | .370∗ |
D7-pSOFA score | 1 (0–2) | 1 (0 –2) | .991∗ |
D1–25 (OH)D concentration | 15.8 (7–18.2) | 16.7 (8.9–21.7) | .119∗ |
D1Vitamin 25 (OH)D | |||
Deficient | 36 (38.7) | 33 (33.7) | .469† |
Insufficient | 57 (61.3) | 65 (66.3) | |
D7–25 (OH)D concentration | 67.7 (58.8–84.5) | 14.3 (8.9–20.6) | .000∗ |
D7Vitamin 25 (OH)D | |||
Deficient | 11 (11.8) | 33 (33.7) | .000† |
Insufficient | 49 (52.7) | 65 (66.3) | |
Sufficient | 33 (35.5) | 0 (0) | |
Vitamin D 25 (OH)D % change | 403.1 (261.4–868.2) | -5 (-11.6 to 0) | .000∗ |
D1-PaO2/FIO2 | 300 (290–360) | 340 (230–400) | .824∗ |
D7-PaO2/FIO2 | 360 (330–400) | 345 (290–400) | .005∗ |
D1-PaO2/FIO2 | |||
Normal | 62 (66.7) | 54 (55.1) | .194† |
Acute lung disease | 25 (26.9) | 32 (32.7) | |
Acute respiratory distress syndrome | 6 (6.5) | 12 (12.2) | |
D7-PaO2/FIO2 | |||
Normal | 87 (93.5) | 68 (69.4) | .000† |
Acute lung disease | 3 (3.2) | 21 (21.4) | |
Acute respiratory distress syndrome | 3 (3.2) | 9 (9.2) |
D1:Day1, D7:Day7.
Qualitative variables described as number (percentage). Quantitative variables described as median (interquartile range).
Bold values represent statistically significant P values were below .05.
Mann–Whitney test.
Chi-square test.