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. 2021 Apr 2;100(13):e25011. doi: 10.1097/MD.0000000000025011

Table 2.

Clinical findings, signs, laboratory measures, and severity scores among the randomly assigned supplementation and placebo groups.

Variable D3 Supplementation group (n = 93) Placebo group (n = 98) P
Temperature 38 (38–39) 38 (38–39) .184
Respiratory rate 45 (40–50) 40 (40–50) .603
Mechanical ventilation 23 (24.7) 34 (34.7) .133
D1-serum Ca 7.9 (7.4–8.9) 8.2 (7.2–9) .392
D1-serum creatinine 0.2 (0.2–0.2) 0.2 (0.1–0.2) .079
D1-serum albumin 3.5 (2.9–4) 3.2 (2.9–3.7) .096
D1-Bilirubin 0.3 (0.3–0.3) 0.3 (0.3–0.4) .502
D1-platelet count 249 (170–370) 227 (170–300) .663
D1-CRP 55 (35–70) 57.5 (45–70) .138
D1-pSOFA score 2 (2–3) 2.5 (2–4) .344
D7-serum Ca 8.9 (8.2–9) 9 (8–9.2) .663
D7-serum creatinine 0.2 (0.2–0.2) 0.2 (0.1–0.2) .220
D7-serum albumin 3.7 (3.5–4) 3.7 (3.1–4) .066
D7-Bilirubin 0.3 (0.3–0.3) 0.3 (0.2–0.3) .070
D7-platelet count 300 (250–350) 250 (250–300) .017
D7-CRP 6 (6–6) 6 (5–35) .370
D7-pSOFA score 1 (0–2) 1 (0 –2) .991
D1–25 (OH)D concentration 15.8 (7–18.2) 16.7 (8.9–21.7) .119
D1Vitamin 25 (OH)D
 Deficient 36 (38.7) 33 (33.7) .469
 Insufficient 57 (61.3) 65 (66.3)
D7–25 (OH)D concentration 67.7 (58.8–84.5) 14.3 (8.9–20.6) .000
D7Vitamin 25 (OH)D
 Deficient 11 (11.8) 33 (33.7) .000
 Insufficient 49 (52.7) 65 (66.3)
 Sufficient 33 (35.5) 0 (0)
Vitamin D 25 (OH)D % change 403.1 (261.4–868.2) -5 (-11.6 to 0) .000
D1-PaO2/FIO2 300 (290–360) 340 (230–400) .824
D7-PaO2/FIO2 360 (330–400) 345 (290–400) .005
D1-PaO2/FIO2
Normal 62 (66.7) 54 (55.1) .194
Acute lung disease 25 (26.9) 32 (32.7)
Acute respiratory distress syndrome 6 (6.5) 12 (12.2)
D7-PaO2/FIO2
 Normal 87 (93.5) 68 (69.4) .000
 Acute lung disease 3 (3.2) 21 (21.4)
 Acute respiratory distress syndrome 3 (3.2) 9 (9.2)

D1:Day1, D7:Day7.

Qualitative variables described as number (percentage). Quantitative variables described as median (interquartile range).

Bold values represent statistically significant P values were below .05.

Mann–Whitney test.

Chi-square test.