Table 3.

Univariate and multivariate analysis of overall survival (OS).

	Univariate analysis		Multivariate analysis
Variable	HR (95% CI)	P value	HR (95% CI)	P value
Age
<50	reference		reference
50–64	1.466 (1.265–1.700)	<.0001∗	1.144 (0.632–2.069)	.657
≥65	3.184 (2.769–3.661)	<.0001∗	3.056 (1.738–5.374)	<.0001∗
Race
White	reference		reference
Black	1.235 (1.107–1.378)	<.0001∗	1.260 (0.868–1.829)	.225
Other	0.740 (0.610–0.899)	.002∗	0.837 (0.406–1.729)	.632
Histology
Ductal	reference		reference
Papillary	0.772 (0.610–0.978)	.032∗	0.432 (0.106–1.756)	.241
Others	1.020 (0.926–1.123)	.691	0.930 (0.591–1.462)	.753
Marital status
Single	reference		reference
Married	0.825 (0.735–0.925)	.001∗	0.556 (0.386–0.799)	.002∗
Separated/Widowed/Divorced	1.469 (1.284–1.682)	<.0001∗	1.071 (0.691–1.659)	.759
AJCC stage
I	reference		reference
II	1.647 (1.467–1.849)	<.0001∗	1.387 (0.935–2.056)	.104
III	2.844 (2.503–3.231)	<.0001∗	3.283 (2.134–5.050)	<.0001∗
IV	8.727 (7.352–10.359)	<.0001∗	14.237 (8.367–24.226)	<.0001∗
Grade
I	reference		reference
II	1.381 (1.180–1.617)	<.0001∗	0.864 (0.515–1.451)	.582
III	1.982 (1.692–2.322)	<.0001∗	1.367 (0.813–2.298)	.238
IV	2.472 (1.830–3.341)	.113	NI	NI
ER status
Positive	reference		reference
Negative	1.215 (0.994–1.484)	.058	2.707 (1.343–5.455)	.005∗
PR status
Positive	reference		reference
Negative	1.290 (1.138–1.462)	<.0001∗	1.633 (1.007–2.648)	.047∗
Her2 status
Positive	reference		reference
Negative	0.708 (0.504–0.997)	.048∗	0.844 (0.575–1.239)	.386
Radiation
No	reference		reference
Yes	1.069 (0.980–1.166)	.134	0.628 (0.454–0.871)	.005∗
Surgery
Refused	reference		reference
Performed	0.222 (0.163–0.320)	<.0001∗	1.143 (0.378–3.456)	.813

^∗represent the P value <.05.