Table 5.
Changes in systolic blood pressure by arsenic exposure, all study centers
| Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | |
| Total Arsenic Quartiles | ||||||||||
| 1 | 0.00 | Referent | 0.00 | Referent | 0.00 | Referent | 0.00 | Referent | 0.00 | Referent |
| 2 | −0.86 | −3.03, 1.31 | −0.35 | −2.00, 1.31 | 0.04 | −1.66, 1.74 | −0.23 | −1.87, 1.41 | −0.15 | −1.83, 1.53 |
| 3 | −1.07 | −3.50, 1.35 | −1.03 | −2.95, 1.31 | −0.29 | −2.28, 1.70 | −0.76 | −2.45, 0.92 | −0.67 | −2.63, 1.29 |
| 4 | 0.79 | −1.82, 3.40 | 1.27 | −0.93, 3.47 | 2.42 | 0.18, 4.66 | 1.74 | −0.22, 3.70 | 1.36 | −0.63, 3.35 |
| Doubling of Total Arsenic | ||||||||||
| 0.62 | −0.22, 1.45 | 0.30 | −0.46, 1.06 | 0.79 | 0.02, 1.56 | 0.43 | −0.18, 1.04 | 0.36 | −0.23, 0.95 | |
| Inorganic and Methylated Arsenic Quartiles | ||||||||||
| 1 | 0.00 | Referent | 0.00 | Referent | 0.00 | Referent | 0.00 | Referent | 0.00 | Referent |
| 2 | −1.03 | −3.01, 0.96 | −1.20 | −2.89, 0.50 | −0.84 | −2.52, 0.85 | −1.08 | −2.66, 0.50 | −0.85 | −2.54, 0.84 |
| 3 | −0.77 | −3.06, 1.52 | −1.27 | −3.17, 0.62 | −0.50 | −2.42, 1.43 | −0.80 | −2.30, 0.70 | −0.58 | −2.52, 1.36 |
| 4 | −0.23 | −2.65, 2.18 | −0.80 | −2.88, 1.27 | 0.40 | −1.70, 2.49 | −0.01 | −1.72, 1.69 | 0.22 | −1.89, 2.34 |
| Doubling of Inorganic and Methylated Arsenic | ||||||||||
| 0.53 | −0.22, 1.27 | 0.16 | −0.54, 0.85 | 0.64 | −0.07, 1.35 | 0.31 | −0.21, 0.82 | 0.58 | −0.11, 1.27 | |
| Measure of Arsenic Toxicokinetics ** | ||||||||||
| −1.03 | −1.43, −0.63 | −0.24 | −0.62, 0.15 | −0.16 | −0.54, 0.23 | -- | -- | −0.13 | −0.51, 0.25 | |
| Doubling of Inorganic Arsenic and Arsenic Toxicokinetics Interaction | ||||||||||
| −0.26 | −0.38, −0.14 | −0.07 | −0.18, 0.04 | −0.05 | −0.16, 0.06 | −0.04 | −0.16, 0.07 | −0.03 | −0.14, 0.08 | |
Models are generalized estimating equation linear regression models for systolic blood pressure, with exchangeable covariance conditional on family membership.
Model 1: Adjusted only for arsenobetaine and log urine creatinine
Model 2: Further adjusted for age, sex, education, drinking status, smoking status, BMI, kidney function, diabetes status, physical activity, diet index, total daily caloric intake
Model 3: Further adjusted for study center
Model 4: Model 3, without adjustment for urine creatinine
Model 5: Model 3, without adjustment for arsenobetaine
**
Principle Component analysis score, not adjusted for urine creatinine.