Table 6.
Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | ||||||
---|---|---|---|---|---|---|---|---|---|---|
β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | |
Total Arsenic Quartiles | ||||||||||
1 | 0.00 | Referent | 0.00 | Referent | 0.00 | Referent | 0.00 | Referent | 0.00 | Referent |
2 | −0.37 | −2.04, 1.29 | 0.22 | −1.20, 1.65 | 0.29 | −1.16, 1.75 | 0.35 | −1.04, 1.74 | 0.04 | −1.41, 1.50 |
3 | 0.70 | −0.87, 2.27 | 0.72 | −0.63, 2.08 | 0.87 | −0.52, 2.25 | 0.99 | −0.24, 2.22 | 0.49 | −0.90, 1.88 |
4 | 1.85 | 0.04, 3.65 | 2.41 | 0.76, 4.05 | 2.64 | 0.98, 4.30 | 2.92 | 1.53, 4.32 | 1.83 | 0.34, 2.32 |
Doubling of Total Arsenic | ||||||||||
0.69 | 0.14, 1.24 | 0.64 | 0.08, 1.20 | 0.73 | 0.17, 1.28 | 0.76 | 0.32, 1.20 | 0.41 | −0.02, 0.84 | |
Inorganic and Methylated Arsenic Quartiles | ||||||||||
1 | 0.00 | Referent | 0.00 | Referent | 0.00 | Referent | 0.00 | Referent | 0.00 | Referent |
2 | −1.53 | −3.15, 0.08 | −1.64 | −3.03, −0.25 | −1.59 | −2.98, −0.19 | −1.43 | −2.77, −0.09 | −1.65 | −3.03,−0.26 |
3 | 0.18 | −1.48, 1.85 | −0.38 | −1.85, 1.09 | −0.26 | −1.73, 1.21 | 0.09 | −1.19, 1.37 | −0.33 | −1.82, 1.15 |
4 | 0.89 | −0.79, 2.56 | 0.61 | −1.08, 2.29 | 0.80 | −0.86, 2.46 | 1.42 | 0.09, 2.74 | 0.66 | −1.00, 2.32 |
Doubling of Inorganic and Methylated Arsenic | ||||||||||
0.57 | 0.08, 1.06 | 0.42 | −0.11, 0.95 | 0.49 | −0.03, 1.02 | 0.59 | 0.17, 1.00 | 0.44 | −0.07, 0.95 | |
Measure of Arsenic Toxicokinetics ** | ||||||||||
−0.70 | −1.01, −0.39 | −0.29 | −0.60, 0.01 | −0.29 | −0.60, 0.02 | -- | -- | −0.28 | −0.59, 0.04 | |
Doubling of Inorganic Arsenic and Arsenic Toxicokinetics Interaction | ||||||||||
−0.20 | −0.30, −0.11 | −0.08 | −0.17, 0.00 | −0.08 | −0.17, 0.00 | −0.09 | −0.17, 0.00 | −0.08 | −0.16, 0.01 |
Models are generalized estimating equation Linear regression models for diastolic blood pressure, with exchangeable covariance conditional on family membership.
Model 1: Adjusted only for arsenobetaine and log urine creatinine
Model 2: Further adjusted for age, sex, education, drinking status, smoking status, BMI, kidney function, diabetes status, physical activity, diet index, total daily caloric intake
Model 3: Further adjusted for study center
Model 4: Model 3, without adjustment for urine creatinine
Model 5: Model 3, without adjustment for arsenobetaine
Principle Component analysis score, not adjusted for urine creatinine.