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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Environ Res. 2021 Feb 11;195:110864. doi: 10.1016/j.envres.2021.110864

Table 6.

Changes in diastolic blood pressure by arsenic exposure, all study centers

   Model 1 Model 2 Model 3 Model 4 Model 5
β 95% CI β 95% CI β 95% CI β 95% CI β 95% CI
Total Arsenic Quartiles
1 0.00 Referent 0.00 Referent 0.00 Referent 0.00 Referent 0.00 Referent
2 −0.37 −2.04, 1.29 0.22 −1.20, 1.65 0.29 −1.16, 1.75 0.35 −1.04, 1.74 0.04 −1.41, 1.50
3 0.70 −0.87, 2.27 0.72 −0.63, 2.08 0.87 −0.52, 2.25 0.99 −0.24, 2.22 0.49 −0.90, 1.88
4 1.85 0.04, 3.65 2.41 0.76, 4.05 2.64 0.98, 4.30 2.92 1.53, 4.32 1.83 0.34, 2.32
Doubling of Total Arsenic
0.69 0.14, 1.24 0.64 0.08, 1.20 0.73 0.17, 1.28 0.76 0.32, 1.20 0.41 −0.02, 0.84
Inorganic and Methylated Arsenic Quartiles
1 0.00 Referent 0.00 Referent 0.00 Referent 0.00 Referent 0.00 Referent
2 −1.53 −3.15, 0.08 −1.64 −3.03, −0.25 −1.59 −2.98, −0.19 −1.43 −2.77, −0.09 −1.65 −3.03,−0.26
3 0.18 −1.48, 1.85 −0.38 −1.85, 1.09 −0.26 −1.73, 1.21 0.09 −1.19, 1.37 −0.33 −1.82, 1.15
4 0.89 −0.79, 2.56 0.61 −1.08, 2.29 0.80 −0.86, 2.46 1.42 0.09, 2.74 0.66 −1.00, 2.32
Doubling of Inorganic and Methylated Arsenic
0.57 0.08, 1.06 0.42 −0.11, 0.95 0.49 −0.03, 1.02 0.59 0.17, 1.00 0.44 −0.07, 0.95
Measure of Arsenic Toxicokinetics **
−0.70 −1.01, −0.39 −0.29 −0.60, 0.01 −0.29 −0.60, 0.02 -- -- −0.28 −0.59, 0.04
Doubling of Inorganic Arsenic and Arsenic Toxicokinetics Interaction
−0.20 −0.30, −0.11 −0.08 −0.17, 0.00 −0.08 −0.17, 0.00 −0.09 −0.17, 0.00 −0.08 −0.16, 0.01

Models are generalized estimating equation Linear regression models for diastolic blood pressure, with exchangeable covariance conditional on family membership.

Model 1: Adjusted only for arsenobetaine and log urine creatinine

Model 2: Further adjusted for age, sex, education, drinking status, smoking status, BMI, kidney function, diabetes status, physical activity, diet index, total daily caloric intake

Model 3: Further adjusted for study center

Model 4: Model 3, without adjustment for urine creatinine

Model 5: Model 3, without adjustment for arsenobetaine

**

Principle Component analysis score, not adjusted for urine creatinine.