FIGURE 2.

LncRNAs sponge microRNAs and then regulate radiosensitivity through different signaling pathways. P: phosphorylated. ①②③④⑦ LncRNAs regulate apoptosis‐mediated radiosensitivity. Specifically, ①②③⑦ lncRNAs affect radiosensitivity by regulating the intrinsic pathway of apoptosis, Hippo, and PI3K/AKT signaling pathways. ⑤ LncRNAs regulate autophagy‐mediated radiosensitivity through HIF‐1α signaling pathway. ①⑥⑦⑧ lncRNAs also regulate EMT‐mediated radiosensitivity via targeting EMT markers and matrix metalloproteinases (MMPs). (Note: The lncRNA‐miRNA complex is regarded as a whole, and the arrows emitted by the complex in the figure represent that the complex promotes the expression of miRNA target genes)