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. 2021 Apr 5;11:7490. doi: 10.1038/s41598-021-85328-w

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Upfront steroids decrease the efficacy of immune checkpoint inhibitors in NSCLCBM. (a) Overall Survival differences between those treated with or without upfront steroids. (b) Multivariable analysis of overall survival. (c) Progression-free survival differences between those treated with or without upfront steroids. (d) Multivariable analysis of progression-free survival. (a) and (c) group differences tested with the Wilcoxon test. (b) and (d) estimates from Cox proportional hazards models and the associations tested with effect likelihood ratio tests.