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. 2021 Apr 5;11:7490. doi: 10.1038/s41598-021-85328-w

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Association of upfront steroids with OS is dependent on NLR. (a) A model was generated utilizing known predictors of OS in NSCLCBM, upfront steroid use, NLR as well as an interaction term between NLR and upfront steroids. The hazard ratio of upfront steroid use was calculated at varying NLRs. Impact of upfront steroids was then analyzed based on NLR less than 4 (b) and NLR greater than or equal to 4 (c).