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. 2021 Apr 5;11:7484. doi: 10.1038/s41598-021-86923-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TOPORS-AS1 mediates the effect of VDR on ovarian cancer cells. (A,B) Western blot results showing reduced β-catenin in IGROV1 and SKOV3 after VDR transfection. (C,D) RT-qPCR results showing TOPORS-AS1 knockdown by si-TOPORS-AS1 in VDR-transfected IGROV1 and SKOV3. (E,F) Western blot results showing increased β-catenin after TOPORS-AS1 knockdown by si-TOPORS-AS1 in VDR-transfected IGROV1 and SKOV3. (G,H) Increased cell proliferation in VDR-transfected IGROV1 and SKOV3 after TOPORS-AS1 knockdown by si-TOPORS-AS1. (I,K) Decreased cell proliferation in IGROV1 and SKOV3 after transfection with TOPORS-AS1. (J,L) Western blot results showing no change in VDR levels over time in IGROV1 and SKOV3 after transfection with TOPORS-AS1. ***P < 0.0001; **P < 0.001.