TABLE 2.

Brain regions with significant GM volume reduction between MSA subgroups and HC.

Index brain region	Cluster size	Peak MNI coordinates			T-values	Z-score	P-value
	(Voxels)	X	Y	Z
HC vs. MSA-MCI
Temporal_Inf_L	871	–34.5	–3	–42	7.67	6.06	0.000*
Fusiform_R	1,544	36	–19.5	–31.5	8.08	6.27	0.000*
Amygdala_R	715	18	−1.5	–13.5	6.22	5.23	0.000*
Temporal_Mid_R	48	60	–27	–12	5.77	5.29	0.002
Putamen_L	457	–19.5	10.5	–12	6.40	5.34	0.000*
Cingulum_Mid_L	31	–4.5	–18	43.5	5.79	4.96	0.011
Temporal_Mid_L	59	–52.5	–55.5	12	6.32	4.94	0.002
HC vs. MSA-NCI
Fusiform_R	913	37.5	–21	–30	4.53	4.12	0.015
Lingual_L	1,894	–18	–61.5	–12	4.73	4.27	0.002
MSA-NCI vs. MSA-MCI
Temporal_Mid_L	1,237	–58.5	–25.5	–6	5.39	4.63	0.001

Clusters of GM identified by SPM analysis (p < 0.05, FWE; threshold K > 20 voxels) L, R: left and right; MNI coordinates: Montreal Neurological Institute coordinates; P-value: cluster level, FWE correct; 0.000*, values < 0.000.