TABLE 5.
Butyrate, acetate, propionate, and total short chain fatty acids (SCFA) concentration (mg/L) after the in vitro fermentation of Previpect, red Previpect, inulin, grape pectin, and grape seed extract (GSPE) using faeces from control subject (n = 6), irritable bowel syndrome (n = 3), ulcerative colitis (n = 3), and Crohn’s disease patients (n = 3) as inocula.
| Control subjects inoculum | Irritable bowel syndrome inoculum | |||||||
| Condition | Butyrate (mg/L) | Acetate (mg/L) | Propionate (mg/L) | Total SCFA (mg/L) | Butyrate (mg/L) | Acetate (mg/L) | Propionate (mg/L) | Total SCFA (mg/L) |
| Negative control | 308.84113.32*** | 573.13131.54*** | 291.56135.91*** | 424.41333.62*** | 293.33193.07*** | 648.05353.88*** | 260.05241.08*** | 1201.43699.48*** |
| Previpect | 1046.76405.03 | 2162.87648.14 | 852.65294.74 | 4062.281147.52 | 767.75301.21 | 2376.85198.45 | 858.1650.08 | 4002.76497.45 |
| Red Previpect | 363.51165.90*** | 771.98159.42*** | 372.74167.04*** | 1508.23400.89*** | 385.26172.43* | 1058.91568.44*** | 407.45158.61*** | 1851.61814.63*** |
| Inulin | 758.78329.93* | 1399.43500.93*** | 609.49275.89** | 2767.701020.29*** | 611.29261.72 | 1585.68528.91*** | 637.40264.57 | 2834.37981.67** |
| Grape pectin | 823.34426.60 | 1840.93663.95 | 736.47322.46 | 3400.741222.30* | 686.42255.15 | 2230.85305.34 | 818.42149.81 | 3735.69426.41 |
| GSPE | 358.20236.40*** | 696.37311.22*** | 337.19255.69*** | 1391.75787.56*** | 328.10159.95* | 1098.00517.74*** | 339.85174.56*** | 1765.94785.88*** |
| Ulcerative colitis inoculum | Crohn’s disease inoculum | |||||||
| Condition | Butyrate (mg/L) | Acetate (mg/L) | Propionate (mg/L) | Total SCFA (mg/L) | Butyrate (mg/L) | Acetate (mg/L) | Propionate (mg/L) | Total SCFA (mg/L) |
| Negative control | 321.3072.58*** | 581.18109.64*** | 359.5744.54*** | 1262.05196.05*** | 409.56161.82*** | 672.40384.30*** | 410.17126.48*** | 1492.13663.08*** |
| Previpect | 759.11130.34 | 1777.52322.23 | 1072.37371.19 | 3609.00724.51 | 1277.54442.09 | 2119.07451.17 | 860.10209.95 | 4256.71995.58 |
| Red Previpect | 354.44135.35*** | 725.15194.70*** | 401.6788.63*** | 1481.26398.82*** | 564.43189.43** | 1000.37326.71*** | 550.92128.02** | 2115.72622.36*** |
| Inulin | 479.00124.67** | 1233.69448.17* | 773.09370.06 | 2485.78924.24* | 769.58334.83* | 1168.70540.70** | 630.37208.31* | 2568.651069.66** |
| Grape pectin | 556.51151.98* | 1465.65286.63* | 709.42122.62* | 2731.58495.27* | 803.03389.87 | 1644.72566.68 | 752.09169.01 | 3199.831078.88 |
| GSPE | 392.7575.89*** | 809.92221.67*** | 426.75153.07*** | 1629.42426.89*** | 404.82168.37*** | 742.60300.13*** | 365.31132.14*** | 1512.73*** |
Significant differences between fibres and Previpect are shown as *p-value < 0.05, **p-value ≤ 0.01, ***p-value ≤ 0.001.