Table 3.
Subject characteristics and SIMPLE score items.
| Parameters | Infants with hsPDA (n = 30) | Infants without PDA (n = 18) | p-value |
|---|---|---|---|
| Gestational age, weeks, median (range) | 25 (21–29) | 26 (24–29) | 0.06 |
| Birth weight, g, median (range) | 720 (340–990) | 760 (620–995) | 0.06 |
| Maternal chorioamnionitis, n (%) | 21 (70) | 5 (28) | 0.005 |
| Lack of antenatal steroid therapy, n (%) | 19 (63) | 4 (22) | 0.006 |
| Hypotension requiring inotropic support, n (%) | 22 (73) | 2 (11) | <0.001 |
| Tachycardia, n (%) | 16 (53) | 3 (17) | 0.01 |
| Oliguria, n (%) | 11 (37) | 1 (5.5) | 0.01 |
| Surfactant treatment, n (%) | 16 (53) | 6 (33) | 0.14 |
| Repeated dosage of surfactant (%) | 9 (30) | 0 (0) | 0.001 |
| High frequency ventilation, n (%) | 9 (30) | 1 (5) | 0.003 |
| Cord blood gas deficit ≥−12 mmol/L, n (%) | 7 (14.6) | 4 (8.3) | 0.92 |
| Need of invasive ventilation, n (%) | 26 (54.2) | 15 (31.3) | 0.75 |
| Metabolic acidosis, pH < 7.35, BD > −4, n (%) | 7 (14.6) | 4 (8.3) | 0.92 |
| Respiratory acidosis, pH < 7.35, PCO2 > 45 mmHg, n (%) | 26 (54.2) | 15 (31.3) | 0.75 |
| Maximum PIP, >18 cm H2O, n (%) | 22 (18–24) | 22 (18–24) | 0.62 |
| FiO2 at admission, >40%, n (%) | 26 (54.2) | 15 (31.3) | 0.75 |