. 2021 Mar 23;12:626107. doi: 10.3389/fphar.2021.626107

TABLE 3.

Diversity of immune effects by paraben EDCs.

	Dose (μg/L)	Species	Cell type	Immune impact
In vitro
BP	2 (×10⁸) (Matsuoka et al., 2018) (Indirect/sensitization)	Mouse	Brachial LN cells	↑	IL-4 and IFN-γ
	2 (×10⁸) (Matsuoka et al., 2018) (Indirect/sensitization)	Mouse	Dendritic cells	↑	Skin to dLN trafficking
	1.17 (×10^–2) (Bairati et al., 1994)	Human	Lymphocytes	↓	Lysozyme release
HP-DP	2,360–2,780 (Uramaru et al., 2014)	Rat	Peritoneal mast cells	↑	Histamine release
PP-DDP	20,800–30,600^a (Uramaru et al., 2014)	Rat	Peritoneal mast cells	↑	Histamine release
IPP	20,800 (Uramaru et al., 2014)	Rat	Peritoneal mast cells	↑	Histamine release
In vivo
BP	200 mg/kg (Hegazy et al., 2015)	Rat (M)	N/A (brain lysates)	↑	NO, IL-6 and TNF-α
BP	200 mg/kg (Hegazy et al., 2015)	Rat (M)	N/A (brain lysates)	↓	IL-1β mRNA