TABLE 2.
Enriched GO biological processes and KEGG pathways of 462 highly expressed genes in subjects with increased 5-years survival probability.
| 2018 GO biological process | −log10 p-value |
| Regulation of immune response (GO: 0050776) | 18.7058 |
| T Cell activation (GO: 0042110) | 14.1283 |
| Positive regulation of lymphocyte proliferation (GO: 0050671) | 9.1974 |
| Cytokine-mediated signaling pathway (GO: 0019221) | 9.2134 |
| Lymphocyte differentiation (GO: 0030098) | 9.2056 |
| T Cell differentiation (GO: 0030217) | 8.9109 |
| Cellular defense response (GO: 0006968) | 8.9468 |
| Regulation of T cell activation (GO: 0050863) | 8.1090 |
| Positive regulation of T cell activation (GO: 0050870) | 7.7301 |
| Inflammatory response (GO: 0006954) | 7.7082 |
| Antigen receptor-mediated signaling pathway (GO: 0050851) | 7.5528 |
| Regulation of T cell proliferation (GO: 0042129) | 7.3419 |
| Cellular response to cytokine stimulus (GO: 0071345) | 7.2260 |
| B Cell activation (GO: 0042113) | 6.4053 |
| Positive regulation of T cell proliferation (GO: 0042102) | 6.4351 |
| Enzyme linked receptor protein signaling pathway (GO: 0007167) | 6.1125 |
| Positive regulation of interferon-gamma production (GO: 0032729) | 6.1040 |
| Peptidyl-tyrosine autophosphorylation (GO: 0038083) | 5.9003 |
| T Cell receptor signaling pathway (GO: 0050852) | 5.6791 |
| Peptidyl-tyrosine phosphorylation (GO: 0018108) | 5.1200 |
| Positive regulation of interferon-gamma secretion (GO: 1902715) | 5.0358 |
| Regulation of B cell proliferation (GO: 0030888) | 5.0545 |
| Negative regulation of T cell activation (GO: 0050868) | 4.9182 |
| Negative regulation of lymphocyte activation (GO: 0051250) | 4.5489 |
| Regulation of defense response to virus by virus (GO: 0050690) | 4.4914 |
| Regulation of lymphocyte activation (GO:0051249) | 4.3648 |
| Positive regulation of B cell proliferation (GO:0030890) | 4.2676 |
| Regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 4.1124 |
| Regulation of interferon-gamma secretion (GO:1902713) | 3.8788 |
| B Cell receptor signaling pathway (GO:0050853) | 3.8575 |
| Dendritic cell chemotaxis (GO:0002407) | 3.7978 |
| Positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.8116 |
| T Cell migration (GO:0072678) | 3.8250 |
| Regulation of B cell receptor signaling pathway (GO:0050855) | 3.6574 |
| Leukocyte cell-cell adhesion (GO:0007159) | 3.5362 |
| Positive regulation of intracellular signal transduction (GO:1902533) | 3.4337 |
| Positive regulation of cytokine biosynthetic process (GO: 0042108) | 3.3738 |
| Negative regulation of lymphocyte proliferation (GO: 0050672) | 3.3443 |
| Positive regulation of MAPK cascade (GO: 0043410) | 3.2727 |
| Hematopoietic progenitor cell differentiation (GO: 0002244) | 2.9904 |
| Regulation of T cell differentiation (GO: 0045580) | 2.9747 |
| Negative regulation of cytokine production (GO: 0001818) | 2.9568 |
| Regulation of lymphocyte differentiation (GO: 0045619) | 2.8904 |
| Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO: 0002460) | 2.9004 |
| Positive regulation of tumor necrosis factor production (GO: 0032760) | 2.9087 |
| Positive regulation of cytokine production (GO: 0001819) | 2.7734 |
| Regulation of interleukin-4 production (GO: 0032673) | 2.7612 |
| Positive regulation of interleukin-4 production (GO: 0032753) | 2.7704 |
| Positive regulation of leukocyte mediated cytotoxicity (GO: 0001912) | 2.7287 |
| T-helper cell lineage commitment (GO: 0002295) | 2.7292 |
| 2019 human KEGG pathways | −log10-p value |
| Hematopoietic cell lineage | 11.7752 |
| T cell receptor signaling pathway | 9.6088 |
| Chemokine signaling pathway | 8.8162 |
| Cell adhesion molecules (CAMs) | 7.9292 |
| Cytokine-cytokine receptor interaction | 7.7867 |
| Primary immunodeficiency | 7.6446 |
| Natural killer cell mediated cytotoxicity | 7.2240 |
| Th17 cell differentiation | 6.0255 |
| Th1 and Th2 cell differentiation | 5.1835 |
| JAK-STAT signaling pathway | 3.7669 |
| Intestinal immune network for IgA production | 3.4458 |
| Graft-versus-host disease | 3.0085 |
| Antigen processing and presentation | 2.7833 |