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. 2021 Mar 23;12:649547. doi: 10.3389/fphys.2021.649547

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Copyright © 2021 Jia, Kang, Tan, Ren, Qu, Tang, Liu, Wang, Xiong and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nicotinamide mononucleotide (NMN) administration before ischemia and during acute phase attenuated tubular senescence in uIRI mice at day 21 after surgery. (A) Representative western blots analysis of γH2A.X (ser139). (B) Bar graph showed reduction of DNA damage in NMN-treated group. (C,D) SA-β-gal staining analysis showed decreased senescent tubular cells in NMN-treated uIRI mice. Scale bars, 50 μm. (E) Relative expression of IL-6, IL-8, and TGF-β1 mRNAs after normalization with β-actin. n = 6–7/group. Data are means ± SD.