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. 2021 Mar 23;11:645475. doi: 10.3389/fonc.2021.645475

Figure 2.

Figure 2

Circulating miR-320a expression correlated with NSCLC patient prognosis. (A) NSCLC histological types. (B) NSCLC stage. (C) Lymph node metastasis status. (D) NSCLC patients smoking history. (E) Alcoholic history of NSCLC patients. (F) Age of NSCLC patients. Bar graphs represent the relative expression of circulating miR-320a from at least n = 3 independent experiments. The data are expressed as mean ± SEM where *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 calculated using unpaired and paired t-test. (G) Kaplan-Meier survival test to determine a correlation between percent overall survival and the circulating miR-320a expression of NSCLC patients. The median expression values of circulating miR-320a in NSCLC patients of 3.98 were used as the cutoff for high and low expression groups [TNM, tumor node metastasis; SCC, squamous cell carcinoma; ADC, adenocarcinoma].