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. 2021 Mar 23;9:626821. doi: 10.3389/fcell.2021.626821

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Copyright © 2021 Krassowski, Pellegrina, Mee, Fradet-Turcotte, Bhat and Reimand.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Outline of ActiveDriverDB. ActiveDriverDB is an interactive proteo-genomics database for interpreting human genetic variation using post-translational modification (PTM) sites. (A,B) The database integrates PTM sites from experimental studies collected from proteomics databases with amino acid substitutions from genome sequencing projects and curated databeses of disease mutations. (C) In the Sequence View, substitutions in PTM sites are classified based on their functional impact as direct (at a PTM residue), proximal or distal (within 1–2 or 3–7 positions of a PTM residue), or network-rewiring. (D) Network-rewiring substitutions at PTM sites are predicted to disrupt short linear motifs or create new motifs bound by kinases and other enzymes. (E) In the Network View, proteins and PTM sites are visualized with their interactions with PTM enzymes (e. g., kinases) and the known drugs targeting the enzymes. (F) The database also provides prioritized lists of genes and pathways, comprehensive data visualizations and an application user interface (API) for analysing custom variant datasets using computational pipelines.