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. 2021 Mar 23;11:630136. doi: 10.3389/fonc.2021.630136

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Copyright © 2021 Morimoto, Yamada, Takumi, Ogura, Takeda, Onoi, Chihara, Taniguchi, Yamada, Hiranuma, Morimoto, Iwasaku, Kaneko, Uchino and Takayama

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kaplan–Meier curves for (A) PFS and (B) OS of patients who received a combination of immunotherapy plus chemotherapy with or without irAEs. Kaplan–Meier curves for (C) PFS and (D) OS of patients who received a combination of immunotherapy plus chemotherapy with mild irAEs or with severe irAEs/without irAEs. Mild irAEs: showing in grade 1-2 irAEs, severe irAEs: showing in grade 3-5 irAEs. irAE, immune-related adverse event; OS, overall survival; PFS, progression-free survival.